Simon Andreasen1,2, Justin A Bishop3, Thomas van Overeem Hansen4, William H Westra3, Anders Bilde1, Christian von Buchwald1, Katalin Kiss5. 1. Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Copenhagen University Hospital, Copenhagen, Denmark. 2. Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Køge, Denmark. 3. Departments of Pathology, Otolaryngology and Oncology, Johns Hopkins Medical Institutions, Baltimore, MD, USA. 4. Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark. 5. Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark.
Abstract
AIMS: Human papillomavirus (HPV) is known as causative for squamous cell carcinoma (SCC) of the oropharynx, but is also found not infrequently in carcinomas of the sinonasal tract. Recently, a subset of these carcinomas was recognized to harbour HPV33 and have a significant morphological overlap with adenoid cystic carcinoma (ACC), a rare and aggressive carcinoma originating in the minor salivary glands. Termed 'HPV-related carcinoma with ACC-like features', only nine cases have been reported. To clarify the occurrence of these tumours we screened a large material for the presence of HPV-related ACC-like carcinoma. The identified tumours were characterized immunohistochemically and with fluorescence in-situ hybridization, and clinicopathological information for all cases is presented. METHODS AND RESULTS: Forty-seven candidate cases were screened for presence of HPV. Six cases were identified and genotyped as HPV types 33, 35, and 56. All six cases had areas of dysplastic mucosal lining and showed remarkable heterogeneous morphologies. MYB, MYBL1, and NFIB genes were intact and, interestingly, staining for MYB protein was largely negative in contrast to what was found in ACC. One patient experienced a local recurrence 11 years after initial treatment and the remaining five patients were alive without evidence of disease. CONCLUSION: We report six new cases of HPV-related ACC-like carcinoma and found that, although in a small material, the prognosis for these patients seems more favourable than for ACC. For the distinction between ACC and HPV-related ACC-like carcinoma, p16, MYB immunohistochemistry or investigation of MYB, MYBL1 and NFIB gene status are valuable.
AIMS: Human papillomavirus (HPV) is known as causative for squamous cell carcinoma (SCC) of the oropharynx, but is also found not infrequently in carcinomas of the sinonasal tract. Recently, a subset of these carcinomas was recognized to harbour HPV33 and have a significant morphological overlap with adenoid cystic carcinoma (ACC), a rare and aggressive carcinoma originating in the minor salivary glands. Termed 'HPV-related carcinoma with ACC-like features', only nine cases have been reported. To clarify the occurrence of these tumours we screened a large material for the presence of HPV-related ACC-like carcinoma. The identified tumours were characterized immunohistochemically and with fluorescence in-situ hybridization, and clinicopathological information for all cases is presented. METHODS AND RESULTS: Forty-seven candidate cases were screened for presence of HPV. Six cases were identified and genotyped as HPV types 33, 35, and 56. All six cases had areas of dysplastic mucosal lining and showed remarkable heterogeneous morphologies. MYB, MYBL1, and NFIB genes were intact and, interestingly, staining for MYB protein was largely negative in contrast to what was found in ACC. One patient experienced a local recurrence 11 years after initial treatment and the remaining five patients were alive without evidence of disease. CONCLUSION: We report six new cases of HPV-related ACC-like carcinoma and found that, although in a small material, the prognosis for these patients seems more favourable than for ACC. For the distinction between ACC and HPV-related ACC-like carcinoma, p16, MYB immunohistochemistry or investigation of MYB, MYBL1 and NFIB gene status are valuable.
Authors: Justin A Bishop; Simon Andreasen; Jen-Fan Hang; Martin J Bullock; Tiffany Y Chen; Alessandro Franchi; Joaquin J Garcia; Douglas R Gnepp; Carmen R Gomez-Fernandez; Stephan Ihrler; Ying-Ju Kuo; James S Lewis; Kelly R Magliocca; Stefan Pambuccian; Ann Sandison; Emmanuelle Uro-Coste; Edward Stelow; Katalin Kiss; William H Westra Journal: Am J Surg Pathol Date: 2017-12 Impact factor: 6.394
Authors: Simon Andreasen; Sushama Varma; Nicholas Barasch; Lester D R Thompson; Markku Miettinen; Lisa Rooper; Edward B Stelow; Tina K Agander; Raja R Seethala; Simion I Chiosea; Preben Homøe; Irene Wessel; Stine R Larsen; Daiva Erentaite; Justin A Bishop; Benedicte P Ulhøi; Katalin Kiss; Linea C Melchior; Jonathan R Pollack; Robert B West Journal: Am J Surg Pathol Date: 2019-04 Impact factor: 6.394
Authors: Petr Šteiner; Simon Andreasen; Petr Grossmann; Lukáš Hauer; Tomáš Vaněček; Markéta Miesbauerová; Thalita Santana; Katalin Kiss; David Slouka; Alena Skálová Journal: Virchows Arch Date: 2018-04-04 Impact factor: 4.064