Literature DB >> 28035594

The therapeutic applications of antimicrobial peptides (AMPs): a patent review.

Hee-Kyoung Kang1, Cheolmin Kim2, Chang Ho Seo2, Yoonkyung Park3,4.   

Abstract

Antimicrobial peptides (AMPs) are small molecules with a broad spectrum of antibiotic activities against bacteria, yeasts, fungi, and viruses and cytotoxic activity on cancer cells, in addition to anti-inflammatory and immunomodulatory activities. Therefore, AMPs have garnered interest as novel therapeutic agents. Because of the rapid increase in drug-resistant pathogenic microorganisms, AMPs from synthetic and natural sources have been developed using alternative antimicrobial strategies. This article presents a broad analysis of patents referring to the therapeutic applications of AMPs since 2009. The review focuses on the universal trends in the effective design, mechanism, and biological evolution of AMPs.

Entities:  

Keywords:  antimicrobial peptide; drug candidate; pathogenic bacteria; therapies

Mesh：

Substances：

Year:  2016        PMID： 28035594     DOI： 10.1007/s12275-017-6452-1

Source DB:  PubMed          Journal:  J Microbiol        ISSN： 1225-8873            Impact factor:   3.422


  50 in total

Review 1.  Emerging themes and therapeutic prospects for anti-infective peptides.

Authors:  Nannette Y Yount; Michael R Yeaman
Journal:  Annu Rev Pharmacol Toxicol       Date:  2012       Impact factor: 13.820

2.  Protegrin-1: a broad-spectrum, rapidly microbicidal peptide with in vivo activity.

Authors:  D A Steinberg; M A Hurst; C A Fujii; A H Kung; J F Ho; F C Cheng; D J Loury; J C Fiddes
Journal:  Antimicrob Agents Chemother       Date:  1997-08       Impact factor: 5.191

3.  Antimicrobial Peptide defenses in amphibian skin.

Authors:  Louise A Rollins-Smith; Laura K Reinert; Chadrick J O'Leary; Laura E Houston; Douglas C Woodhams
Journal:  Integr Comp Biol       Date:  2005-01       Impact factor: 3.326

4.  θ-Defensins: cyclic peptides with endless potential.

Authors:  Robert I Lehrer; Alex M Cole; Michael E Selsted
Journal:  J Biol Chem       Date:  2012-06-14       Impact factor: 5.157

5.  In vivo antimalarial activity of the endophytic actinobacteria, Streptomyces SUK 10.

Authors:  Mohd Shukri Baba; Noraziah Mohamad Zin; Zainal Abidin Abu Hassan; Jalifah Latip; Florence Pethick; Iain S Hunter; RuAngelie Edrada-Ebel; Paul R Herron
Journal:  J Microbiol       Date:  2015-12-02       Impact factor: 3.422

6.  Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils.

Authors:  J Turner; Y Cho; N N Dinh; A J Waring; R I Lehrer
Journal:  Antimicrob Agents Chemother       Date:  1998-09       Impact factor: 5.191

7.  In vitro antibacterial properties of pexiganan, an analog of magainin.

Authors:  Y Ge; D L MacDonald; K J Holroyd; C Thornsberry; H Wexler; M Zasloff
Journal:  Antimicrob Agents Chemother       Date:  1999-04       Impact factor: 5.191

8.  Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry.

Authors:  Bushra Yasin; Wei Wang; Mabel Pang; Natalia Cheshenko; Teresa Hong; Alan J Waring; Betsy C Herold; Elizabeth A Wagar; Robert I Lehrer
Journal:  J Virol       Date:  2004-05       Impact factor: 5.103

9.  Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor.

Authors:  M Zasloff
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

10.  STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : I. PREPARATION OF THE AGENT. ITS ACTIVITY IN VITRO.

Authors:  R J Dubos
Journal:  J Exp Med       Date:  1939-06-30       Impact factor: 14.307
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  76 in total

1.  Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries.

Authors:  Ashley T Tucker; Sean P Leonard; Cory D DuBois; Gregory A Knauf; Ashley L Cunningham; Claus O Wilke; M Stephen Trent; Bryan W Davies
Journal:  Cell       Date:  2018-01-04       Impact factor: 41.582

Review 2.  Trends in peptide drug discovery.

Authors:  Markus Muttenthaler; Glenn F King; David J Adams; Paul F Alewood
Journal:  Nat Rev Drug Discov       Date:  2021-02-03       Impact factor: 84.694

Review 3.  Rediscovery of antimicrobial peptides as therapeutic agents.

Authors:  Minkyung Ryu; Jaeyeong Park; Ji-Hyun Yeom; Minju Joo; Kangseok Lee
Journal:  J Microbiol       Date:  2021-02-01       Impact factor: 3.422

4.  Profiling of Polar Metabolites in Mouse Feces Using Four Analytical Platforms to Study the Effects Of Cathelicidin-Related Antimicrobial Peptide in Alcoholic Liver Disease.

Authors:  Liqing He; Fengyuan Li; Xinmin Yin; Patrick Bohman; Seongho Kim; Craig J McClain; Wenke Feng; Xiang Zhang
Journal:  J Proteome Res       Date:  2019-06-12       Impact factor: 4.466

Review 5.  Antimicrobial hydrogels: promising materials for medical application.

Authors:  Kerong Yang; Qing Han; Bingpeng Chen; Yuhao Zheng; Kesong Zhang; Qiang Li; Jincheng Wang
Journal:  Int J Nanomedicine       Date:  2018-04-12

6.  Self-Association of Antimicrobial Peptides: A Molecular Dynamics Simulation Study on Bombinin.

Authors:  Peicho Petkov; Elena Lilkova; Nevena Ilieva; Leandar Litov
Journal:  Int J Mol Sci       Date:  2019-11-01       Impact factor: 5.923

7.  Gold nanoparticle-DNA aptamer-assisted delivery of antimicrobial peptide effectively inhibits Acinetobacter baumannii infection in mice.

Authors:  Jaeyeong Park; Eunkyoung Shin; Ji-Hyun Yeom; Younkyung Choi; Minju Joo; Minho Lee; Je Hyeong Kim; Jeehyeon Bae; Kangseok Lee
Journal:  J Microbiol       Date:  2021-12-29       Impact factor: 3.422

8.  Direct antimicrobial activity of cationic amphipathic peptide WLBU2 against Staphylococcus aureus biofilms is enhanced in physiologic buffered saline.

Authors:  Jonathan B Mandell; John A Koch; Berthony Deslouches; Kenneth L Urish
Journal:  J Orthop Res       Date:  2020-06-09       Impact factor: 3.494

9.  Effect of Non-natural Hydrophobic Amino Acids on the Efficacy and Properties of the Antimicrobial Peptide C18G.

Authors:  Morgan A Hitchner; Matthew R Necelis; Devanie Shirley; Gregory A Caputo
Journal:  Probiotics Antimicrob Proteins       Date:  2021-04       Impact factor: 4.609

10.  Stability and Activity of the Antimicrobial Peptide Leg1 in Solution and on Meat and Its Optimized Generation from Chickpea Storage Protein.

Authors:  Marie-Louise Heymich; Showmika Srirangan; Monika Pischetsrieder
Journal:  Foods       Date:  2021-05-25
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