Literature DB >> 28035573

Can Motor Recovery in Stroke Be Improved by Non-invasive Brain Stimulation?

John C Rothwell1.   

Abstract

At the present time, there is enormous interest in methods of non-invasive brain stimulation. These interact with ongoing neural activity, mainly in cerebral cortex, and have measureable effects on behaviours in healthy people. More intriguingly, they appear to have effects on synaptic plasticity that persist even after stimulation has ceased. This has led, as might be expected, to the proposal that brain stimulation methods might be therapeutically useful in rehabilitation. The rationale is that physical therapy involves learning new patterns of activity to compensate for those lost to the stroke. Enhanced "plasticity" produced by brain stimulation might increase the ability to learn and enhance therapy. However, if things really were as simple as this, brain stimulation would be on its way to becoming a standard addition to treatment in all departments of rehabilitation. The fact that this has not happened means that something is not quite correct. Is the theory untenable, or are the methods of stimulation suboptimal?

Entities:  

Keywords:  Cortical; Magnetic stimulation; Paired associative stimulation (PAS); Synaptic plasticity (STDP); Transcranial direct current stimulation (TDCS)

Mesh:

Year:  2016        PMID: 28035573     DOI: 10.1007/978-3-319-47313-0_17

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN: 0065-2598            Impact factor:   2.622


  7 in total

1.  Evidence for Subcortical Plasticity after Paired Stimulation from a Wearable Device.

Authors:  Maria Germann; Stuart N Baker
Journal:  J Neurosci       Date:  2021-01-13       Impact factor: 6.167

2.  Assessment of Corticospinal Excitability in Awake Rodents Using EMG-Controlled Intracortical Stimulation.

Authors:  Windsor K C Ting; Derek Burns; Maxime Huot-Lavoie; Christian Ethier
Journal:  Bio Protoc       Date:  2021-12-20

Review 3.  Recovery from stroke: current concepts and future perspectives.

Authors:  Christian Grefkes; Gereon R Fink
Journal:  Neurol Res Pract       Date:  2020-06-16

Review 4.  Recent advances in the role of excitation-inhibition balance in motor recovery post-stroke.

Authors:  Ioana-Florentina Grigoras; Charlotte J Stagg
Journal:  Fac Rev       Date:  2021-06-23

5.  Bimanual motor skill learning after stroke: Combining robotics and anodal tDCS over the undamaged hemisphere: An exploratory study.

Authors:  Chloë De Laet; Benoît Herman; Audrey Riga; Benoît Bihin; Maxime Regnier; Maria Leeuwerck; Jean-Marc Raymackers; Yves Vandermeeren
Journal:  Front Neurol       Date:  2022-08-18       Impact factor: 4.086

6.  Transcutaneous spinal direct current stimulation increases corticospinal transmission and enhances voluntary motor output in humans.

Authors:  Tomofumi Yamaguchi; Mikkel M Beck; Eva R Therkildsen; Christian Svane; Christian Forman; Jakob Lorentzen; Bernard A Conway; Jesper Lundbye-Jensen; Svend S Geertsen; Jens B Nielsen
Journal:  Physiol Rep       Date:  2020-08

7.  Plastic changes in primate motor cortex following paired peripheral nerve stimulation.

Authors:  Bonne Habekost; Maria Germann; Stuart N Baker
Journal:  J Neurophysiol       Date:  2020-12-02       Impact factor: 2.714

  7 in total

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