S Tabur1, H Korkmaz2, E Baysal3, E Hatipoglu4, I Aytac5, E Akarsu1. 1. Division of Endocrinology and Diabetes, Department of Internal Medicine, Gaziantep University Medical Faculty, Gaziantep, Turkey. 2. Division of Endocrinology and Diabetes, Department of Internal Medicine, Endocrinology and Metabolic Disease, Edirne State Hospital, 22030, Edirne, Turkey. drhkorkmaz@yahoo.com.tr. 3. Department of Otorhinolaryngology, Inonu University Medical Faculty, Malatya, Turkey. 4. Division of Endocrinology and Diabetes, Department of Internal Medicine, Biruni University, Istanbul, Turkey. 5. Department of Otorhinolaryngology, Mardin Midyat State Hospital, Mardin, Turkey.
Abstract
OBJECTIVE: The aim of this study is to determine the changes involving auditory system in cases with acromegaly. MATERIALS AND METHODS: Otological examinations of 41 cases with acromegaly (uncontrolled n = 22, controlled n = 19) were compared with those of age and gender-matched 24 healthy subjects. Whereas the cases with acromegaly underwent examination with pure tone audiometry (PTA), speech audiometry for speech discrimination (SD), tympanometry, stapedius reflex evaluation and otoacoustic emission tests, the control group did only have otological examination and PTA. Additionally, previously performed paranasal sinus-computed tomography of all cases with acromegaly and control subjects were obtained to measure the length of internal acoustic canal (IAC). RESULTS: PTA values were higher (p < 0.001 for right ears and p = 0.001 for left ears), and SD scores were (p = 0.002 for right ears and p = 0.002 for left ears) lower in acromegalic patients. IAC width in acromegaly group was narrower compared to that in control group (p = 0.03 for right ears and p = 0.02 for left ears). When only cases with acromegaly were taken into consideration, PTA values in left ears had positive correlation with growth hormone and insulin-like growth factor-1 levels (r = 0.4, p = 0.02 and r = 0.3, p = 0.03). Of all cases with acromegaly 13 (32%) had hearing loss in at least one ear, 7 (54%) had sensorineural type and 6 (46%) had conductive type hearing loss. CONCLUSION: Acromegaly may cause certain changes in the auditory system in cases with acromegaly. The changes in the auditory system may be multifactorial causing both conductive and sensorioneural defects.
OBJECTIVE: The aim of this study is to determine the changes involving auditory system in cases with acromegaly. MATERIALS AND METHODS: Otological examinations of 41 cases with acromegaly (uncontrolled n = 22, controlled n = 19) were compared with those of age and gender-matched 24 healthy subjects. Whereas the cases with acromegaly underwent examination with pure tone audiometry (PTA), speech audiometry for speech discrimination (SD), tympanometry, stapedius reflex evaluation and otoacoustic emission tests, the control group did only have otological examination and PTA. Additionally, previously performed paranasal sinus-computed tomography of all cases with acromegaly and control subjects were obtained to measure the length of internal acoustic canal (IAC). RESULTS: PTA values were higher (p < 0.001 for right ears and p = 0.001 for left ears), and SD scores were (p = 0.002 for right ears and p = 0.002 for left ears) lower in acromegalicpatients. IAC width in acromegaly group was narrower compared to that in control group (p = 0.03 for right ears and p = 0.02 for left ears). When only cases with acromegaly were taken into consideration, PTA values in left ears had positive correlation with growth hormone and insulin-like growth factor-1 levels (r = 0.4, p = 0.02 and r = 0.3, p = 0.03). Of all cases with acromegaly 13 (32%) had hearing loss in at least one ear, 7 (54%) had sensorineural type and 6 (46%) had conductive type hearing loss. CONCLUSION:Acromegaly may cause certain changes in the auditory system in cases with acromegaly. The changes in the auditory system may be multifactorial causing both conductive and sensorioneural defects.
Authors: Borivoj B Babic; Milan S Petakov; Vojko B Djukic; Sanja I Ognjanovic; Nenad A Arsovic; Tatjana V Isailovic; Jovica D Milovanovic; Djuro Macut; Svetozar S Damjanovic Journal: Otol Neurotol Date: 2006-09 Impact factor: 2.311
Authors: Tomasz Zatonski; Marek Bolanowski; Aleksandra Skrzypek; Monika Morawska-Kochman; Marcin Kaluzny; Katarzyna Zatonska; Krzysztof Moron; Roman Badowski; Tomasz Krecicki Journal: Neuro Endocrinol Lett Date: 2010 Impact factor: 0.765