Zhong Zheng Jia1, Wei Shi2, Jin Long Shi3, Dan Dan Shen4, Hong Mei Gu5, Xue Jun Zhou6. 1. Department of Radiology, Affiliated Hospital of Nantong University, No. 20 Xisi Road Nantong 226001, Jiangsu, People's Republic of China. Electronic address: jzz2397@163.com. 2. Department of Neurosurgery, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu, People's Republic of China. Electronic address: sw740104@hotmail.com. 3. Department of Neurosurgery, Affiliated Hospital of Nantong University, 20 Xisi Road, Nantong 226001, Jiangsu, People's Republic of China. Electronic address: shij_ns@163.com. 4. Department of Radiology, Affiliated Hospital of Nantong University, No. 20 Xisi Road Nantong 226001, Jiangsu, People's Republic of China. Electronic address: 1021121084@qq.com. 5. Department of Radiology, Affiliated Hospital of Nantong University, No. 20 Xisi Road Nantong 226001, Jiangsu, People's Republic of China. Electronic address: guhongmei71@163.com. 6. Department of Radiology, Affiliated Hospital of Nantong University, No. 20 Xisi Road Nantong 226001, Jiangsu, People's Republic of China. Electronic address: 56516400@qq.com.
Abstract
PURPOSE: Perfusion computed tomography (PCT) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provide independent measurements of biomarkers related to tumor perfusion. The aim of this study was to compare the two techniques in assessing glioblastoma microvasculature. MATERIALS AND METHODS: Twenty-five patients diagnosed with glioblastoma (14 males and 11 females; 51±11years old, ranging from 33 to 70 years) were includede in this prospective study. All patients underwent both PCT and DCE-MRI. Imaging was performed on a 256-slice CT scanner and a 3-T MRI system. PCT yielded permeability surface-area product (PS) using deconvolution physiological models; meanwhile, DCE-MRI determined volume transfer constant (Ktrans) using the Tofts-Kermode compartment model. All cases were submitted to surgical intervention, and CD105-microvascular density (CD105-MVD) was measured in each glioblastoma specimen. Then, Spearman's correlation coefficients and Bland-Altman plots were obtained for PS, Ktrans and CD105-MVD. P<0.05 was considered statistically significant. RESULTS: Tumor PS and Ktrans values were correlated with CD105-MVD (r=0.644, P<0.001; r=0.683, P<0.001). In addition, PS was correlated with Ktrans in glioblastoma (r=0.931, P<0.001). Finally, Bland-Altman plots showed no significant differences between PS and Ktrans (P=0.063). CONCLUSION: PCT and DCE-MRI measurements of glioblastoma perfusion biomarkers have similar results, suggesting that both techniques may have comparable utility. Therefore, PCT may serve as an alternative modality to DCE-MRI for the in vivo evaluation of glioblastoma microvasculature.
PURPOSE: Perfusion computed tomography (PCT) and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provide independent measurements of biomarkers related to tumor perfusion. The aim of this study was to compare the two techniques in assessing glioblastoma microvasculature. MATERIALS AND METHODS: Twenty-five patients diagnosed with glioblastoma (14 males and 11 females; 51±11years old, ranging from 33 to 70 years) were includede in this prospective study. All patients underwent both PCT and DCE-MRI. Imaging was performed on a 256-slice CT scanner and a 3-T MRI system. PCT yielded permeability surface-area product (PS) using deconvolution physiological models; meanwhile, DCE-MRI determined volume transfer constant (Ktrans) using the Tofts-Kermode compartment model. All cases were submitted to surgical intervention, and CD105-microvascular density (CD105-MVD) was measured in each glioblastoma specimen. Then, Spearman's correlation coefficients and Bland-Altman plots were obtained for PS, Ktrans and CD105-MVD. P<0.05 was considered statistically significant. RESULTS:TumorPS and Ktrans values were correlated with CD105-MVD (r=0.644, P<0.001; r=0.683, P<0.001). In addition, PS was correlated with Ktrans in glioblastoma (r=0.931, P<0.001). Finally, Bland-Altman plots showed no significant differences between PS and Ktrans (P=0.063). CONCLUSION: PCT and DCE-MRI measurements of glioblastoma perfusion biomarkers have similar results, suggesting that both techniques may have comparable utility. Therefore, PCT may serve as an alternative modality to DCE-MRI for the in vivo evaluation of glioblastoma microvasculature.
Authors: Bart R J van Dijken; Peter Jan van Laar; Marion Smits; Jan Willem Dankbaar; Roelien H Enting; Anouk van der Hoorn Journal: J Magn Reson Imaging Date: 2019-01 Impact factor: 4.813
Authors: M J van Amerongen; A M Vos; W van der Woude; I D Nagtegaal; J H W de Wilt; J J Fütterer; J J Hermans Journal: PLoS One Date: 2021-01-26 Impact factor: 3.240