Esther-Lee Marcus1, Hana Yosef2, Gadi Borkow3, Yehezkel Caine4, Ady Sasson4, Allon E Moses5. 1. Chronic Ventilator-Dependent Division, Herzog Hospital, Jerusalem, Israel. Electronic address: elm@zahav.net.il. 2. Infection Control Unit, Herzog Hospital, Jerusalem, Israel. 3. Cupron Inc, Herzelia, Israel. 4. Chronic Ventilator-Dependent Division, Herzog Hospital, Jerusalem, Israel. 5. Department of Clinical Microbiology and Infectious Diseases, Hadassah Medical Center, Jerusalem, Israel.
Abstract
BACKGROUND:Copper oxide has potent wide-spectrum biocidal properties. The purpose of this study is to determine if replacing hospital textiles with copper oxide-impregnated textiles reduces the following health care-associated infection (HAI) indicators: antibiotic treatment initiation events (ATIEs), fever days, and antibiotic usage in hospitalized chronic ventilator-dependent patients. METHODS: A 7-month, crossover, double-blind controlled trial including all patients in 2 ventilator-dependent wards in a long-term care hospital. For 3 months (period 1), one ward received copper oxide-impregnated textiles and the other received untreated textiles. After a 1-month washout period of using regular textiles, for 3 months (period 2) the ward that received the treated textiles received the control textiles and vice versa. The personnel were blinded to which were treated or control textiles. There were no differences in infection control measures during the study. RESULTS: There were reductions of 29.3% (P = .002), 55.5% (P < .0001), 23.0% (P < .0001), and 27.5% (P < .0001) in the ATIEs, fever days (>37.6°C), days of antibiotic treatment, and antibiotic defined daily dose per 1,000 hospitalization days, respectively, when using the copper oxide-impregnated textiles. CONCLUSIONS: Use of copper oxide-impregnated biocidal textiles in a long-term care ward of ventilator-dependent patients was associated with a significant reduction of HAI indicators and antibiotic utilization. Using copper oxide-impregnated biocidal textiles may be an important measure aimed at reducing HAIs in long-term care medical settings.
RCT Entities:
BACKGROUND:Copper oxide has potent wide-spectrum biocidal properties. The purpose of this study is to determine if replacing hospital textiles with copper oxide-impregnated textiles reduces the following health care-associated infection (HAI) indicators: antibiotic treatment initiation events (ATIEs), fever days, and antibiotic usage in hospitalized chronic ventilator-dependent patients. METHODS: A 7-month, crossover, double-blind controlled trial including all patients in 2 ventilator-dependent wards in a long-term care hospital. For 3 months (period 1), one ward received copper oxide-impregnated textiles and the other received untreated textiles. After a 1-month washout period of using regular textiles, for 3 months (period 2) the ward that received the treated textiles received the control textiles and vice versa. The personnel were blinded to which were treated or control textiles. There were no differences in infection control measures during the study. RESULTS: There were reductions of 29.3% (P = .002), 55.5% (P < .0001), 23.0% (P < .0001), and 27.5% (P < .0001) in the ATIEs, fever days (>37.6°C), days of antibiotic treatment, and antibiotic defined daily dose per 1,000 hospitalization days, respectively, when using the copper oxide-impregnated textiles. CONCLUSIONS: Use of copper oxide-impregnated biocidal textiles in a long-term care ward of ventilator-dependent patients was associated with a significant reduction of HAI indicators and antibiotic utilization. Using copper oxide-impregnated biocidal textiles may be an important measure aimed at reducing HAIs in long-term care medical settings.
Authors: Joanne Purves; Jamie Thomas; Gustavo P Riboldi; Marta Zapotoczna; Emma Tarrant; Peter W Andrew; Alejandra Londoño; Paul J Planet; Joan A Geoghegan; Kevin J Waldron; Julie A Morrissey Journal: Environ Microbiol Date: 2018-03-26 Impact factor: 5.491
Authors: C P Dunne; P D Askew; T Papadopoulos; I C Gouveia; M Ahonen; M Modic; N F Azevedo; S Schulte; P Cosemans; A Kahru; K Murzyn; C W Keevil; M Riool; M M Keinänen-Toivola Journal: J Hosp Infect Date: 2020-04-09 Impact factor: 3.926
Authors: Guilherme Schneider; Felipe Lazarini Bim; Álvaro Francisco Lopes de Sousa; Evandro Watanabe; Denise de Andrade; Inês Fronteira Journal: Rev Lat Am Enfermagem Date: 2021-04-01