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Literature DB >> 28034471

Pentoxifylline - a review of its use in osteoradionecrosis.

Abstract

Pentoxifylline has been used to treat complications related to fibrosis for over 20 years. Formerly used to treat those after radiotherapy such as osteoradionecrosis (ORN), it is now being tried for medication-related osteonecrosis of the jaw (MRONJ), which can occur after prolonged use of bisphosphonates. We review theories on the formation of fibrosis in patients with ORN, discuss the pharmacology of pentoxifylline and vitamin E, and report published outcomes. To our knowledge no prospective randomised controlled trial has investigated the benefits of these agents in cases of ORN, but reported outcomes in many published case series are encouraging.

Entities: Chemical Disease Species

Keywords: Pentoxifylline; head and neck; osteoradionecrosis; radiotherapy; review

Mesh：

Substances：
Pentoxifylline

Year: 2016 PMID： 28034471 DOI： 10.1016/j.bjoms.2016.12.006

Source DB: PubMed Journal: Br J Oral Maxillofac Surg ISSN： 0266-4356 Impact factor: 1.651

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Cited

6 in total

Review 1. Treatment of late sequelae after radiotherapy for head and neck cancer.

Authors: Primož Strojan; Katherine A Hutcheson; Avraham Eisbruch; Jonathan J Beitler; Johannes A Langendijk; Anne W M Lee; June Corry; William M Mendenhall; Robert Smee; Alessandra Rinaldo; Alfio Ferlito
Journal: Cancer Treat Rev Date: 2017-07-18 Impact factor: 12.111

2. Pentoxifylline and vitamin E reduce the severity of radiotherapy-induced oral mucositis and dysphagia in head and neck cancer patients: a randomized, controlled study.

Authors: Rana Sayed; Lamia El Wakeel; Amr S Saad; Mohamed Kelany; Manal El-Hamamsy
Journal: Med Oncol Date: 2019-11-21 Impact factor: 3.064

Pentoxifylline - a review of its use in osteoradionecrosis.

Review 1. Treatment of late sequelae after radiotherapy for head and neck cancer.

2. Pentoxifylline and vitamin E reduce the severity of radiotherapy-induced oral mucositis and dysphagia in head and neck cancer patients: a randomized, controlled study.

Review 3. Osteoradionecrosis of the Maxilla: Conservative Management and Reconstructive Considerations.

Review 4. The Potential Therapeutic Role of Mesenchymal Stem Cells-Derived Exosomes in Osteoradionecrosis.

5. Osteoradionecrosis of the Hip, a Troublesome Complication of Radiation Therapy: Case Series and Systematic Review.

6. The effects of pentoxifylline and tocopherol in jaw osteomyelitis.