Literature DB >> 28034353

New Therapeutics to Modulate Mitochondrial Function in Neurodegenerative Disorders.

Heather M Wilkins1, Jill K Morris2.   

Abstract

BACKGROUND: Mitochondrial function and energy metabolism are impaired in neurodegenerative diseases. There is evidence for these functional declines both within the brain and systemically in Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis. Due to these observations, therapeutics targeted to alter mitochondrial function and energy pathways are increasingly studied in pre-clinical and clinical settings.
METHODS: The goal of this article was to review therapies with specific implications on mitochondrial energy metabolism published through May 2016 that have been tested for treatment of neurodegenerative diseases.
RESULTS: We discuss implications for mitochondrial dysfunction in neurodegenerative diseases and how this drives new therapeutic initiatives.
CONCLUSION: Thus far, treatments have achieved varying degrees of success. Further investigation into the mechanisms driving mitochondrial dysfunction and bioenergetic failure in neurodegenerative diseases is warranted. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Alzheimer's disease; Amyotrophic Lateral Sclerosis; Bioenergetics; Mitochondria; Oxidative Stress; Parkinson's disease; neurodegeneration

Mesh：

Year:  2017        PMID： 28034353      PMCID： PMC5466080          DOI： 10.2174/1381612822666161230144517

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN： 1381-6128            Impact factor:   3.116


  352 in total

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Review 5.  Mitochondrial Dysfunctions: A Red Thread across Neurodegenerative Diseases.

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6.  Evaluation of the Antioxidant and Neuroprotectant Activities of New Asymmetrical 1,3-Diketones.

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