J Fest1, R Ruiter2, F J A van Rooij2, L G M van der Geest3, V E P P Lemmens4, M A Ikram2, J W Coebergh5, B H Stricker6, C H J van Eijck1. 1. Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands. 2. Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. 3. Department of Research, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, The Netherlands. 4. Department of Research, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, The Netherlands; Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands. 5. Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands. 6. Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: b.stricker@erasmusmc.nl.
Abstract
BACKGROUND: In the Netherlands, like in many other European countries, pancreatic cancer mortality was found to be systematically higher than the incidence. This suggests that there is an underestimation of the reported incidence of pancreatic cancer. AIM: We aimed to study the incidence of pancreatic cancer in the Rotterdam area and to compare this with the national level. METHODS: This study is embedded in the Rotterdam Study (RS), an ongoing population-based prospective cohort study of people aged 45 years and above, enrolled between 1989 till 2006. Details on incident pancreatic cancer cases were available until 2013. Age-specific incidence rates were calculated and compared with data available in the Netherlands Cancer Registry. RESULTS: At baseline 14,922 participants were at risk of developing pancreatic cancer. Median follow-up time was 16.4 person years per person. In total, 113 participants developed pancreatic cancer. Rates increased with age with an incidence rate of 109.9 (95% confidence interval [CI]; 85.7-138.8) per 100,000 person years for people older than 75. This is higher than the currently reported 55.9-89.2 per 100,000 person year. Of the 113 cases identified in the RS, only 67.3% was reported as pancreatic cancer in the Netherlands Cancer Registry. Cases that were not registered were significantly older and had significantly poorer survival. CONCLUSION: The incidence of pancreatic cancer, as registered by the Netherlands Cancer Registry, is an underestimation. Patients, not registered by the cancer registry, have a significantly poorer survival. Consequently, we probably overestimate the already poor survival of pancreatic cancer.
BACKGROUND: In the Netherlands, like in many other European countries, pancreatic cancer mortality was found to be systematically higher than the incidence. This suggests that there is an underestimation of the reported incidence of pancreatic cancer. AIM: We aimed to study the incidence of pancreatic cancer in the Rotterdam area and to compare this with the national level. METHODS: This study is embedded in the Rotterdam Study (RS), an ongoing population-based prospective cohort study of people aged 45 years and above, enrolled between 1989 till 2006. Details on incident pancreatic cancer cases were available until 2013. Age-specific incidence rates were calculated and compared with data available in the Netherlands Cancer Registry. RESULTS: At baseline 14,922 participants were at risk of developing pancreatic cancer. Median follow-up time was 16.4 person years per person. In total, 113 participants developed pancreatic cancer. Rates increased with age with an incidence rate of 109.9 (95% confidence interval [CI]; 85.7-138.8) per 100,000 person years for people older than 75. This is higher than the currently reported 55.9-89.2 per 100,000 person year. Of the 113 cases identified in the RS, only 67.3% was reported as pancreatic cancer in the Netherlands Cancer Registry. Cases that were not registered were significantly older and had significantly poorer survival. CONCLUSION: The incidence of pancreatic cancer, as registered by the Netherlands Cancer Registry, is an underestimation. Patients, not registered by the cancer registry, have a significantly poorer survival. Consequently, we probably overestimate the already poor survival of pancreatic cancer.
Authors: Lydia G M van der Geest; Nadia Haj Mohammad; Marc G H Besselink; Valery E P P Lemmens; Johanneke E A Portielje; Hanneke W M van Laarhoven; J Hanneke W Wilmink Journal: Cancer Med Date: 2017-10-16 Impact factor: 4.452
Authors: Kimberly D van der Willik; Rikje Ruiter; Frank J A van Rooij; Jolande Verkroost-van Heemst; Sander J Hogewoning; Karin C A A Timmermans; Otto Visser; Sanne B Schagen; M Arfan Ikram; Bruno H Ch Stricker Journal: Int J Cancer Date: 2019-11-07 Impact factor: 7.396
Authors: Jesse Fest; Lisanne S Vijfhuizen; Jelle J Goeman; Olga Veth; Anni Joensuu; Markus Perola; Satu Männistö; Eivind Ness-Jensen; Kristian Hveem; Toomas Haller; Neeme Tonisson; Kairit Mikkel; Andres Metspalu; Cornelia M van Duijn; Arfan Ikram; Bruno H Stricker; Rikje Ruiter; Casper H J van Eijck; Gert-Jan B van Ommen; Peter A C ʼt Hoen Journal: Endocrinology Date: 2019-07-01 Impact factor: 4.736
Authors: M Arfan Ikram; Guy Brusselle; Mohsen Ghanbari; André Goedegebure; M Kamran Ikram; Maryam Kavousi; Brenda C T Kieboom; Caroline C W Klaver; Robert J de Knegt; Annemarie I Luik; Tamar E C Nijsten; Robin P Peeters; Frank J A van Rooij; Bruno H Stricker; André G Uitterlinden; Meike W Vernooij; Trudy Voortman Journal: Eur J Epidemiol Date: 2020-05-04 Impact factor: 8.082
Authors: Inger L Abma; Lianne C G Roelofs; Marion B van der Kolk; Sasja F Mulder; Henk J Schers; Rosella P M G Hermens; Philip J van der Wees Journal: Eur J Cancer Care (Engl) Date: 2022-04-13 Impact factor: 2.328
Authors: Lydia G M van der Geest; Casper H J van Eijck; Bas Groot Koerkamp; Valery E P P Lemmens; Olivier R Busch; Pauline A J Vissers; Johanna W Wilmink; Marc G Besselink Journal: Cancer Med Date: 2018-09-06 Impact factor: 4.452