Literature DB >> 2803308

Cell adhesion activity of non-specific cross-reacting antigen (NCA) and carcinoembryonic antigen (CEA) expressed on CHO cell surface: homophilic and heterophilic adhesion.

S Oikawa1, C Inuzuka, M Kuroki, Y Matsuoka, G Kosaki, H Nakazato.   

Abstract

Cell adhesion activity of carcinoembryonic antigen (CEA) and non-specific cross-reacting antigen (NCA) has been analysed by using CHO cells which had been transfected with cDNAs and are ectopically expressing each antigen on their surface. CEA expressing CHO tended to aggregate easily within 30 min after being suspended by trypsinization. Cell adhesion assay between 51Cr labelled cells and monolayered cells showed both homophilic and heterophilic interaction, the extent of which was CEA-CEA much greater than CEA-NCA greater than NCA-NCA. These reactions were completely inhibited by Fab' fragment of anti-CEA antibody. The results strongly suggested that CEA and NCA function as Ca++ independent cell adhesion molecules by homophilic and heterophilic interactions.

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Year:  1989        PMID： 2803308     DOI： 10.1016/0006-291x(89)91679-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  51 in total

Review 1.  The role of CD15-(Le(X))-related carbohydrates in neutrophil adhesion.

Authors:  M A Kerr; S C Stocks
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2.  Diverse oligomeric states of CEACAM IgV domains.

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Journal:  Proc Natl Acad Sci U S A       Date:  2015-10-19       Impact factor: 11.205

3.  Assembly and analysis of cosmid contigs in the CEA-gene family region of human chromosome 19.

Authors:  K Tynan; A Olsen; B Trask; P de Jong; J Thompson; W Zimmermann; A Carrano; H Mohrenweiser
Journal:  Nucleic Acids Res       Date:  1992-04-11       Impact factor: 16.971

4.  Binding of nonspecific cross-reacting antigen, a granulocyte membrane glycoprotein, to Escherichia coli expressing type 1 fimbriae.

Authors:  S L Sauter; S M Rutherfurd; C Wagener; J E Shively; S A Hefta
Journal:  Infect Immun       Date:  1991-07       Impact factor: 3.441

5.  Characterization of new members of the pregnancy-specific beta 1-glycoprotein family.

Authors:  W Y Chan; Q X Zheng; J McMahon; L A Tease
Journal:  Mol Cell Biochem       Date:  1991-08-14       Impact factor: 3.396

6.  Blocking the attachment of cancer cells in vivo with DNA aptamers displaying anti-adhesive properties against the carcinoembryonic antigen.

Authors:  Erik W Orava; Aws Abdul-Wahid; Eric H-B Huang; Amirul Islam Mallick; Jean Gariépy
Journal:  Mol Oncol       Date:  2013-04-11       Impact factor: 6.603

7.  Metastatic potential of human colorectal carcinoma SW1222 cells transfected with cDNA encoding carcinoembryonic antigen.

Authors:  J Hashino; Y Fukuda; S Oikawa; H Nakazato; T Nakanishi
Journal:  Clin Exp Metastasis       Date:  1994-07       Impact factor: 5.150

8.  Pregnancy specific beta 1-glycoprotein in human intestine.

Authors:  W L Shupert; W Y Chan
Journal:  Mol Cell Biochem       Date:  1993-03-24       Impact factor: 3.396

9.  Stimulation of neutrophil adhesion by antibodies recognizing CD15 (Le(X)) and CD15-expressing carcinoembryonic antigen-related glycoprotein NCA-160.

Authors:  S C Stocks; M A Kerr
Journal:  Biochem J       Date:  1992-11-15       Impact factor: 3.857

10.  A monoclonal antibody disrupting cell-cell adhesion of rat ascites hepatoma cells.

Authors:  S Ohshima; Y Ishimaru; M Honda; S Ohkawara; M Ogawa
Journal:  Cell Tissue Res       Date:  1993-08       Impact factor: 5.249
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