Anniina Haro1,2, Tuomas Saxlin1,3,4, Anna Liisa Suominen1,3,5,6, Antti Jula7, Matti Knuuttila4,8, Pekka Ylöstalo1,3,8. 1. Institute of Dentistry, University of Eastern Finland, Kuopio, Finland. 2. City of Äänekoski, Public Health Centre, Oral Health Care Services, Äänekoski, Finland. 3. Department of Oral and Maxillofacial Surgery, Kuopio University Hospital, Kuopio, Finland. 4. Institute of Dentistry, University of Oulu, Oulu, Finland. 5. The Living Environment and Health Unit, National Institute for Health and Welfare, Kuopio, Finland. 6. The Health Monitoring Unit, National Institute for Health and Welfare, Helsinki, Finland. 7. National Institute for Health and Welfare (THL), Turku, Finland. 8. Unit of Oral Health Sciences, Medical Research Center Oulu (MRC Oulu), Oulu University Hospital and Oulu University, Oulu, Finland.
Abstract
AIM: The aim of this study was to investigate whether the systemic response against a local inflammatory process in periodontium is dependent on the individual's serum lipid composition. MATERIAL AND METHODS: This study was based on a subpopulation of the Health 2000 Survey that included 878 subjects who were aged between 45 and 64 years, dentate, non-diabetic and non-rheumatic. The inflammatory condition of periodontium was measured by means of the number of teeth with deepened (4 mm or deeper) periodontal pockets. Systemic inflammation was assessed by means of the serum levels of interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α). The association between an inflammatory condition in the periodontium and the systemic inflammatory response was analysed using linear regression models. RESULTS: The number of teeth with deepened periodontal pockets was associated with elevated serum IL-6 levels among subjects with an unfavourable lipid composition (low-density lipoprotein cholesterol ≥3.7 mmol/l or high-density lipoprotein cholesterol <1.3 mmol/l). There was no association between serum TNF-α levels and the number of teeth with deepened periodontal pockets in these data. CONCLUSION: The systemic response against the inflammatory condition of periodontium varied between individuals. The variation appeared to be dependent on the serum lipid composition or related factors.
AIM: The aim of this study was to investigate whether the systemic response against a local inflammatory process in periodontium is dependent on the individual's serum lipid composition. MATERIAL AND METHODS: This study was based on a subpopulation of the Health 2000 Survey that included 878 subjects who were aged between 45 and 64 years, dentate, non-diabetic and non-rheumatic. The inflammatory condition of periodontium was measured by means of the number of teeth with deepened (4 mm or deeper) periodontal pockets. Systemic inflammation was assessed by means of the serum levels of interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α). The association between an inflammatory condition in the periodontium and the systemic inflammatory response was analysed using linear regression models. RESULTS: The number of teeth with deepened periodontal pockets was associated with elevated serum IL-6 levels among subjects with an unfavourable lipid composition (low-density lipoprotein cholesterol ≥3.7 mmol/l or high-density lipoprotein cholesterol <1.3 mmol/l). There was no association between serum TNF-α levels and the number of teeth with deepened periodontal pockets in these data. CONCLUSION: The systemic response against the inflammatory condition of periodontium varied between individuals. The variation appeared to be dependent on the serum lipid composition or related factors.