Literature DB >> 28032760

Spongian-16-one Diterpenes and Their Anatomical Distribution in the Australian Nudibranch Goniobranchus collingwoodi.

Louise C Forster1, Anne E Winters1, Karen L Cheney1, Pradeep Dewapriya1, Robert J Capon1, Mary J Garson1.   

Abstract

Six new (1-6) spongian-16-one analogues have been characterized from the Australian nudibranch species Goniobranchus collingwoodi, along with four known spongian-16-one derivatives. The structures and relative configuration were suggested by spectroscopic analyses informed by molecular modeling. Dissection of animal tissue revealed that the mantle and viscera differ in their terpene composition. Whole body extracts were not toxic to brine shrimp (Artemia sp.), but were unpalatable to palaemon shrimp (Palaemon serenus) at a concentration found within the nudibranch. Individual terpenes were not cytotoxic to human lung (NCIH-460), colorectal (SW620), and liver (HepG2) cancer cells.

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Year:  2016        PMID： 28032760     DOI： 10.1021/acs.jnatprod.6b00936

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  4 in total

Review 1.  Bioactive Compounds from Marine Heterobranchs.

Authors:  Conxita Avila; Carlos Angulo-Preckler
Journal:  Mar Drugs       Date:  2020-12-21       Impact factor: 5.118

Review 2.  High-value compounds from the molluscs of marine and estuarine ecosystems as prospective functional food ingredients: An overview.

Authors:  Kajal Chakraborty; Minju Joy
Journal:  Food Res Int       Date:  2020-08-31       Impact factor: 6.475

3.  New diterpenes from the marine sponge Spongionella sp. overcome drug resistance in prostate cancer by inhibition of P-glycoprotein.

Authors:  Sergey A Dyshlovoy; Larisa K Shubina; Tatyana N Makarieva; Jessica Hauschild; Nadja Strewinsky; Alla G Guzii; Alexander S Menshov; Roman S Popov; Boris B Grebnev; Tobias Busenbender; Su Jung Oh-Hohenhorst; Tobias Maurer; Derya Tilki; Markus Graefen; Carsten Bokemeyer; Valentin A Stonik; Gunhild von Amsberg
Journal:  Sci Rep       Date:  2022-08-09       Impact factor: 4.996

4.  Expanding the Repertoire of Spongian-16-One Derivatives in Australian Nudibranchs of the Genus Goniobranchus and Evaluation of Their Anatomical Distribution.

Authors:  Louise C Forster; Jack K Clegg; Karen L Cheney; Mary J Garson
Journal:  Mar Drugs       Date:  2021-11-29       Impact factor: 5.118
  4 in total

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