Literature DB >> 2803274

Effects of re-feeding after prolonged starvation on pyruvate dehydrogenase activities in heart, diaphragm and selected skeletal muscles of the rat.

M C Sugden1, M J Holness.   

Abstract

We investigated the capacity for pyruvate oxidation in skeletal muscle, diaphragm and heart after starvation and re-feeding. Starvation for 48 h decreased pyruvate dehydrogenase (PDH) activity in soleus (by 47%), extensor digitorum longus (64%), gastrocnemius (86%), diaphragm (87%), adductor longus (90%), tibialis anterior (92%) and heart (99%). Chow re-feeding increased PDH activity in all muscles to 43-78% of the fed value within 2 h. However, complete re-activation was not observed for at least 4-6 h, during which time hepatic glycogen was replenished. We discuss the importance of muscle PDH activity in relation to sparing carbohydrate for hepatic glycogen synthesis.

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Year:  1989        PMID： 2803274      PMCID： PMC1133320          DOI： 10.1042/bj2620669

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

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2.  Hindlimb muscle fiber populations of five mammals.

Authors:  M A Ariano; R B Armstrong; V R Edgerton
Journal:  J Histochem Cytochem       Date:  1973-01       Impact factor: 2.479

3.  Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles.

Authors:  P J Randle; E A Newsholme; P B Garland
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4.  Glucose metabolism in perfused skeletal muscle. Pyruvate dehydrogenase activity in starvation, diabetes and exercise.

Authors:  S A Hagg; S I Taylor; N B Ruberman
Journal:  Biochem J       Date:  1976-08-15       Impact factor: 3.857

5.  Hepatic glycogen synthesis on carbohydrate re-feeding after starvation. A regulatory role for pyruvate dehydrogenase in liver and extrahepatic tissues.

Authors:  M J Holness; T J French; M C Sugden
Journal:  Biochem J       Date:  1986-04-15       Impact factor: 3.857

6.  Effects of fasting on tissue glucose utilization in conscious resting rats. Major glucose-sparing effect in working muscles.

Authors:  T Issad; L Pénicaud; P Ferré; J Kandé; M A Baudon; J Girard
Journal:  Biochem J       Date:  1987-08-15       Impact factor: 3.857

7.  Effect of the fatty acid oxidation inhibitor 2-tetradecylglycidic acid on pyruvate dehydrogenase complex activity in starved and alloxan-diabetic rats.

Authors:  I D Caterson; S J Fuller; P J Randle
Journal:  Biochem J       Date:  1982-10-15       Impact factor: 3.857

8.  Effect of nutritional status on insulin sensitivity in vivo and tissue enzyme activities in the rat.

Authors:  Y T Kruszynska; J G McCormack
Journal:  Biochem J       Date:  1989-03-15       Impact factor: 3.857

9.  Pyruvate dehydrogenase kinase/activator in rat heart mitochondria, Assay, effect of starvation, and effect of protein-synthesis inhibitors of starvation.

Authors:  A L Kerbey; P J Randle
Journal:  Biochem J       Date:  1982-07-15       Impact factor: 3.857

10.  Glucose metabolism in perfused skeletal muscle. Effects of starvation, diabetes, fatty acids, acetoacetate, insulin and exercise on glucose uptake and disposition.

Authors:  M Berger; S A Hagg; M N Goodman; N B Ruderman
Journal:  Biochem J       Date:  1976-08-15       Impact factor: 3.857
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  9 in total

Review 1.  The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles?

Authors:  Mary C Sugden; Mark J Holness
Journal:  Islets       Date:  2011-11-01       Impact factor: 2.694

2.  Control of respiration in skeletal muscle at rest.

Authors:  A Chinet
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3.  An improved assay for pyruvate dehydrogenase in liver and heart.

Authors:  P J Randle
Journal:  Biochem J       Date:  1992-06-01       Impact factor: 3.857

4.  Glucose utilization and disposal in cardiothoracic and skeletal muscles during the starved-to-fed transition in the rat.

Authors:  M C Sugden; Y L Liu; M J Holness
Journal:  Biochem J       Date:  1990-11-15       Impact factor: 3.857

5.  Time courses of the responses of pyruvate dehydrogenase activities to short-term starvation in diaphragm and selected skeletal muscles of the rat.

Authors:  M J Holness; Y L Liu; M C Sugden
Journal:  Biochem J       Date:  1989-12-15       Impact factor: 3.857

6.  Effects of non-esterified fatty acid availability on insulin stimulated glucose utilisation and tissue pyruvate dehydrogenase activity in the rat.

Authors:  Y T Kruszynska; J G McCormack; N McIntyre
Journal:  Diabetologia       Date:  1990-07       Impact factor: 10.122

7.  Glucose utilization in heart, diaphragm and skeletal muscle during the fed-to-starved transition.

Authors:  M J Holness; M C Sugden
Journal:  Biochem J       Date:  1990-08-15       Impact factor: 3.857

8.  Glucose utilization by skeletal muscles in vivo in experimental hyperthyroidism in the rat.

Authors:  M C Sugden; Y L Liu; M J Holness
Journal:  Biochem J       Date:  1990-10-15       Impact factor: 3.857

9.  Changes in lipoprotein lipase activities in adipose tissue, heart and skeletal muscle during continuous or interrupted feeding.

Authors:  M C Sugden; M J Holness; R M Howard
Journal:  Biochem J       Date:  1993-05-15       Impact factor: 3.857
  9 in total

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