Literature DB >> 28031576

Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases.

John A Hamilton1, Andrew D Cook1, Paul P Tak2.   

Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF; also known as CSF1), granulocyte colony-stimulating factor (G-CSF) and interleukin-3 (IL-3) can each play a part in the host response to injury and infection, and there is burgeoning interest in targeting these CSFs in inflammatory and autoimmune disorders, as well as in cancer. For success in clinical medicine, therapeutic targeting will need to be delineated from current strategies. The individual CSFs have unique biological roles, suggesting that they could be used to target specific conditions. This Review compares the CSFs, with a focus on how they could be targeted, discusses the relevant clinical trial data and summarizes the potential clinical applications of targeting each CSF. Importantly, we discuss the novelty of CSF biology and attempt to clarify some of the surrounding misconceptions and issues that can affect therapeutic decisions.

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Year:  2016        PMID： 28031576     DOI： 10.1038/nrd.2016.231

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  255 in total

1.  A novel role for IL-3: human monocytes cultured in the presence of IL-3 and IL-4 differentiate into dendritic cells that produce less IL-12 and shift Th cell responses toward a Th2 cytokine pattern.

Authors:  Susanne Ebner; Susanne Hofer; Van Anh Nguyen; Christina Fürhapter; Manfred Herold; Peter Fritsch; Christine Heufler; Nikolaus Romani
Journal:  J Immunol       Date:  2002-06-15       Impact factor: 5.422

2.  Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: Role for peripheral TNFα, IL-1β and IL-10.

Authors:  Thacyana T Carvalho; Sergio M Borghi; Felipe A Pinho-Ribeiro; Sandra S Mizokami; Thiago M Cunha; Sergio H Ferreira; Fernando Q Cunha; Rubia Casagrande; Waldiceu A Verri
Journal:  Eur J Pharmacol       Date:  2015-01-10       Impact factor: 4.432

3.  "Emergency" granulopoiesis in G-CSF-deficient mice in response to Candida albicans infection.

Authors:  S Basu; G Hodgson; H H Zhang; M Katz; C Quilici; A R Dunn
Journal:  Blood       Date:  2000-06-15       Impact factor: 22.113

4.  Mice lacking three myeloid colony-stimulating factors (G-CSF, GM-CSF, and M-CSF) still produce macrophages and granulocytes and mount an inflammatory response in a sterile model of peritonitis.

Authors:  Margaret L Hibbs; Cathy Quilici; Nicole Kountouri; John F Seymour; Jane E Armes; Antony W Burgess; Ashley R Dunn
Journal:  J Immunol       Date:  2007-05-15       Impact factor: 5.422

5.  A Phase 1 study of the safety, pharmacokinetics and anti-leukemic activity of the anti-CD123 monoclonal antibody CSL360 in relapsed, refractory or high-risk acute myeloid leukemia.

Authors:  Simon Z He; Samantha Busfield; David S Ritchie; Mark S Hertzberg; Simon Durrant; Ian D Lewis; Paula Marlton; Andrew J McLachlan; Ian Kerridge; Kenneth F Bradstock; Glen Kennedy; Andrew W Boyd; Trina M Yeadon; Angel F Lopez; Hayley S Ramshaw; Harry Iland; Simone Bamford; Megan Barnden; Mark DeWitte; Russell Basser; Andrew W Roberts
Journal:  Leuk Lymphoma       Date:  2014-11-20

6.  IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells.

Authors:  Rebecca Noster; René Riedel; Mir-Farzin Mashreghi; Helena Radbruch; Lutz Harms; Claudia Haftmann; Hyun-Dong Chang; Andreas Radbruch; Christina E Zielinski
Journal:  Sci Transl Med       Date:  2014-06-18       Impact factor: 17.956

7.  GM-CSF Enhances Macrophage Glycolytic Activity In Vitro and Improves Detection of Inflammation In Vivo.

Authors:  Parmanand Singh; Silvia González-Ramos; Marina Mojena; César Eduardo Rosales-Mendoza; Hamed Emami; Jeffrey Swanson; Alex Morss; Zahi A Fayad; James H F Rudd; Jeffrey Gelfand; Marta Paz-García; Paloma Martín-Sanz; Lisardo Boscá; Ahmed Tawakol
Journal:  J Nucl Med       Date:  2016-04-14       Impact factor: 10.057

8.  GM-CSF mediates autoimmunity by enhancing IL-6-dependent Th17 cell development and survival.

Authors:  Ivo Sonderegger; Giandomenica Iezzi; Reinhard Maier; Nicole Schmitz; Michael Kurrer; Manfred Kopf
Journal:  J Exp Med       Date:  2008-09-08       Impact factor: 14.307

9.  Cytokines in chronic inflammatory arthritis. I. Failure to detect T cell lymphokines (interleukin 2 and interleukin 3) and presence of macrophage colony-stimulating factor (CSF-1) and a novel mast cell growth factor in rheumatoid synovitis.

Authors:  G S Firestein; W D Xu; K Townsend; D Broide; J Alvaro-Gracia; A Glasebrook; N J Zvaifler
Journal:  J Exp Med       Date:  1988-11-01       Impact factor: 14.307

10.  Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology.

Authors:  Adrian Olmos-Alonso; Sjoerd T T Schetters; Sarmi Sri; Katharine Askew; Renzo Mancuso; Mariana Vargas-Caballero; Christian Holscher; V Hugh Perry; Diego Gomez-Nicola
Journal:  Brain       Date:  2016-01-08       Impact factor: 13.501
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  59 in total

Review 1.  Therapeutic targeting of trained immunity.

Authors:  Willem J M Mulder; Jordi Ochando; Leo A B Joosten; Zahi A Fayad; Mihai G Netea
Journal:  Nat Rev Drug Discov       Date:  2019-07       Impact factor: 84.694

2.  Microglia mediate postoperative hippocampal inflammation and cognitive decline in mice.

Authors:  Xiaomei Feng; Martin Valdearcos; Yosuke Uchida; David Lutrin; Mervyn Maze; Suneil K Koliwad
Journal:  JCI Insight       Date:  2017-04-06

Review 3.  Chemotherapy-induced metastasis: mechanisms and translational opportunities.

Authors:  George S Karagiannis; John S Condeelis; Maja H Oktay
Journal:  Clin Exp Metastasis       Date:  2018-01-06       Impact factor: 5.150

Review 4.  What is new in pain modification in osteoarthritis?

Authors:  Rachel E Miller; Joel A Block; Anne-Marie Malfait
Journal:  Rheumatology (Oxford)       Date:  2018-05-01       Impact factor: 7.580

5.  Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages.

Authors:  Amy T Hsu; Tanya J Lupancu; Ming-Chin Lee; Andrew J Fleetwood; Andrew D Cook; John A Hamilton; Adrian Achuthan
Journal:  J Biol Chem       Date:  2018-06-05       Impact factor: 5.157

Review 6.  Rethinking Communication in the Immune System: The Quorum Sensing Concept.

Authors:  Luca Antonioli; Corrado Blandizzi; Pál Pacher; Martin Guilliams; György Haskó
Journal:  Trends Immunol       Date:  2019-01-02       Impact factor: 16.687

7.  TNF and granulocyte macrophage-colony stimulating factor interdependence mediates inflammation via CCL17.

Authors:  Andrew D Cook; Ming-Chin Lee; Reem Saleh; Hsu-Wei Khiew; Anne D Christensen; Adrian Achuthan; Andrew J Fleetwood; Derek C Lacey; Julia E Smith; Irmgard Förster; John A Hamilton
Journal:  JCI Insight       Date:  2018-03-22

Review 8.  Growth Factors as Immunotherapeutic Targets in Cardiovascular Disease.

Authors:  John E Mindur; Filip K Swirski
Journal:  Arterioscler Thromb Vasc Biol       Date:  2019-05-16       Impact factor: 8.311

Review 9.  Investigational therapies targeting the granulocyte macrophage colony-stimulating factor receptor-α in rheumatoid arthritis: focus on mavrilimumab.

Authors:  Andrew D Cook; John A Hamilton
Journal:  Ther Adv Musculoskelet Dis       Date:  2018-01-11       Impact factor: 5.346

10.  Granulocyte-colony-stimulating factor (G-CSF) signaling in spinal microglia drives visceral sensitization following colitis.

Authors:  Lilian Basso; Tamia K Lapointe; Mircea Iftinca; Candace Marsters; Morley D Hollenberg; Deborah M Kurrasch; Christophe Altier
Journal:  Proc Natl Acad Sci U S A       Date:  2017-10-02       Impact factor: 11.205
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