Vesna Prčkovska1,2, Willem Huijbers3,4, Aaron Schultz3, Laura Ortiz-Teran2, Cleofe Peña-Gomez2, Pablo Villoslada1,5, Keith Johnson2,6,7, Reisa Sperling3,6,7, Jorge Sepulcre2,3. 1. Center of Neuroimmunology, Institut d'Investigacions Biomedica August Pi Sunyer, Barcelona, Spain. 2. Gordon Center For Medical Imaging, Department of Radiology, Division of Nuclear Medicine and Molecular Imaging, Harvard Medical School, Boston, Massachusetts. 3. Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Boston, Massachusetts. 4. Department of Population Health Sciences, German Center for Neurodegenerative Diseases, Bonn, Germany. 5. Department of Neurology, University of California, San Francisco, California. 6. Department of Neurology, Centre for Alzheimer Research and Treatment, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. 7. Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Abstract
OBJECTIVES AND DESIGN: Neuronal responses adapt to familiar and repeated sensory stimuli. Enhanced synchrony across wide brain systems has been postulated as a potential mechanism for this adaptation phenomenon. Here, we used recently developed graph theory methods to investigate hidden connectivity features of dynamic synchrony changes during a visual repetition paradigm. Particularly, we focused on strength connectivity changes occurring at local and distant brain neighborhoods. PRINCIPAL OBSERVATIONS: We found that connectivity reorganization in visual modal cortex-such as local suppressed connectivity in primary visual areas and distant suppressed connectivity in fusiform areas-is accompanied by enhanced local and distant connectivity in higher cognitive processing areas in multimodal and association cortex. Moreover, we found a shift of the dynamic functional connections from primary-visual-fusiform to primary-multimodal/association cortex. CONCLUSIONS: These findings suggest that repetition-suppression is made possible by reorganization of functional connectivity that enables communication between low- and high-order areas. Hum Brain Mapp 38:1965-1976, 2017.
OBJECTIVES AND DESIGN: Neuronal responses adapt to familiar and repeated sensory stimuli. Enhanced synchrony across wide brain systems has been postulated as a potential mechanism for this adaptation phenomenon. Here, we used recently developed graph theory methods to investigate hidden connectivity features of dynamic synchrony changes during a visual repetition paradigm. Particularly, we focused on strength connectivity changes occurring at local and distant brain neighborhoods. PRINCIPAL OBSERVATIONS: We found that connectivity reorganization in visual modal cortex-such as local suppressed connectivity in primary visual areas and distant suppressed connectivity in fusiform areas-is accompanied by enhanced local and distant connectivity in higher cognitive processing areas in multimodal and association cortex. Moreover, we found a shift of the dynamic functional connections from primary-visual-fusiform to primary-multimodal/association cortex. CONCLUSIONS: These findings suggest that repetition-suppression is made possible by reorganization of functional connectivity that enables communication between low- and high-order areas. Hum Brain Mapp 38:1965-1976, 2017.
Authors: Koene R A Van Dijk; Trey Hedden; Archana Venkataraman; Karleyton C Evans; Sara W Lazar; Randy L Buckner Journal: J Neurophysiol Date: 2009-11-04 Impact factor: 2.714