| Literature DB >> 28029457 |
Agata J Pacuła1, Katarzyna B Kaczor2, Angelika Wojtowicz2, Jędrzej Antosiewicz2, Anna Janecka3, Angelika Długosz3, Tomasz Janecki4, Jacek Ścianowski5.
Abstract
A series of N-alkyl benzisoselenazol-3(2H)-ones has been obtained and transformed to corresponding diselenides by the reduction with sodium borohydride. Additionally, efficient methodology for the oxidative Se-N bond formation by potassium iodate has been presented, new conversion of diselenide to benzisoselenazolone was observed. The GPx-like activity of all synthetized derivatives has been evaluated by NMR. N-Allyl diselenide was up to five times better antioxidant than ebselen. Anticancer capacity towards MCF7 and DU145 cancer cells has been also tested. The highest antiproliferative activity was obtained for N-cyclohexyl benzisoselenazolone.Entities:
Keywords: Antioxidant activity; Benzisoselenazolones; Cytotoxicity; Diselenides
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Year: 2016 PMID： 28029457 DOI： 10.1016/j.bmc.2016.10.018
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641