Cai-Yun Ma1,2, Jing-Hua Liu3, Jian-Xun Liu4, Da-Zhuo Shi5, Zhen-Ye Xu1, Shao-Ping Wang1, Min Jia5, Fu-Hai Zhao5, Yue-Rong Jiang5, Qin Ma1, Hong-Yu Peng1, Yuan Lu1, Ze Zheng1, Feng-Xue Ren2. 1. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China. 2. Department of Cardiology, Aviation General Hospital, Beijing, 100016, China. 3. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 100029, China. liujinghua@vip.sina.com. 4. Institute of Basic Medical Sciences, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China. liujx0324@sina.com. 5. Cardiovascular Diseases Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China.
Abstract
OBJECTIVE: To investigate the relationship between inflammatory factors and two Chinese medicine (CM) syndrome types of qi stagnation and blood stasis (QSBS) and qi deficiency and blood stasis (QDBS) in patients with acute coronary syndrome (ACS). METHODS: Sixty subjects with ACS, whose pathogenesis changes belongs to qi disturbance blood stasis syndrome, were divided into 2 groups: 30 in the QSBS group and 30 in the QDBS group. The comparative analysis on them was carried out through comparing general information, coronary angiography and inflammatory factors including intracellular adhesion molecule-1 (ICAM-1), chitinase-3-like protein 1 (YKL-40) and lipoprotein-associated phospholipase A2 (Lp-PLA2). RESULTS: Compared with the QSBS group, Lp-PLA2 and YKL-40 levels in the QDBS group showed no-significant difference (P>0.05); ICAM-1 was significantly higher in the QDBS group than in the QSBS group in the pathological processes of qi disturbance and blood stasis syndrome of ACS (P<0.05). CONCLUSIONS: Inflammatory factor ICAM-1 may be an objective basis for syndrome typing of QSBS and QDBS, which provides a research direction for standardization research of CM syndrome types.
OBJECTIVE: To investigate the relationship between inflammatory factors and two Chinese medicine (CM) syndrome types of qi stagnation and blood stasis (QSBS) and qi deficiency and blood stasis (QDBS) in patients with acute coronary syndrome (ACS). METHODS: Sixty subjects with ACS, whose pathogenesis changes belongs to qi disturbance blood stasis syndrome, were divided into 2 groups: 30 in the QSBS group and 30 in the QDBS group. The comparative analysis on them was carried out through comparing general information, coronary angiography and inflammatory factors including intracellular adhesion molecule-1 (ICAM-1), chitinase-3-like protein 1 (YKL-40) and lipoprotein-associated phospholipase A2 (Lp-PLA2). RESULTS: Compared with the QSBS group, Lp-PLA2 and YKL-40 levels in the QDBS group showed no-significant difference (P>0.05); ICAM-1 was significantly higher in the QDBS group than in the QSBS group in the pathological processes of qi disturbance and blood stasis syndrome of ACS (P<0.05). CONCLUSIONS: Inflammatory factor ICAM-1 may be an objective basis for syndrome typing of QSBS and QDBS, which provides a research direction for standardization research of CM syndrome types.
Entities:
Keywords:
Chinese medicine; chitinase-3-like protein 1; coronary heart disease; inflammation; intracellular adhesion molecule-1; lipoprotein-associated phospholipase A2; qi deficiency and blood stasis syndrome; qi stagnation and blood stasis syndrome
Authors: E Braunwald; R M Califf; C P Cannon; K A Fox; V Fuster; W B Gibler; R A Harrington; S B King; N S Kleiman; P Theroux; E J Topol; F Van de Werf; H D White; J T Willerson Journal: Am J Med Date: 2000-01 Impact factor: 4.965
Authors: Giuseppe Maiolino; Livia Lenzini; Luigi Pedon; Maurizio Cesari; Teresa Maria Seccia; Anna Chiara Frigo; Giacomo Rossitto; Brasilina Caroccia; Gian Paolo Rossi Journal: J Cardiovasc Med (Hagerstown) Date: 2015-01 Impact factor: 2.160
Authors: Raymond E Eid; Deepak A Rao; Jing Zhou; Sheng-fu L Lo; Hooman Ranjbaran; Amy Gallo; Seth I Sokol; Steven Pfau; Jordan S Pober; George Tellides Journal: Circulation Date: 2009-03-02 Impact factor: 29.690