Literature DB >> 28027071

Covert Hepatic Encephalopathy: Can My Patient Drive?

Jawaid Shaw1, Jasmohan S Bajaj.   

Abstract

Liver cirrhosis is a public health problem and hepatic encephalopathy is one of its main complications, which can be either overt meaning thereby evident and readily diagnosed, or covert/minimal (covert hepatic encephalopathy-CHE) needing psychometric testing for diagnosis. Patients with CHE hepatic encephalopathy have deficits in multiple domains including visuospatial assessment, attention, response inhibition, working memory, along with psychomotor speed to name a few areas. These patients have poor navigational skills, get fatigued easily, and demonstrate poor insight into their driving deficits. The combination of all these leads them to have poor driving skills leading to traffic violations and crashes as demonstrated not only on the simulation testing but also in real-life driving events. There are multiple psychometric tests for CHE testing but these are not easily available and there is no uniform consensus on the gold standard testing as of yet. It does not automatically connote that all patients who test positive on driving simulation testing are unfit to drive. The physicians are encouraged to take driving history from the patient and the caregivers on every encounter and focus their counseling efforts more on patients with recent history of traffic crashes, with abnormal simulation studies and history of alcohol cessation within last year. As physicians are not trained to determine fitness to drive, their approach toward CHE patients in regards to driving restrictions should be driven by ethical principles while as respecting the local laws.

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Year:  2017        PMID: 28027071      PMCID: PMC5218855          DOI: 10.1097/MCG.0000000000000764

Source DB:  PubMed          Journal:  J Clin Gastroenterol        ISSN: 0192-0790            Impact factor:   3.062


  76 in total

1.  Prevalence and natural history of subclinical hepatic encephalopathy in cirrhosis.

Authors:  A Das; R K Dhiman; V A Saraswat; M Verma; S R Naik
Journal:  J Gastroenterol Hepatol       Date:  2001-05       Impact factor: 4.029

2.  Minimal hepatic encephalopathy: a vehicle for accidents and traffic violations.

Authors:  Jasmohan S Bajaj; Muhammad Hafeezullah; Raymond G Hoffmann; Kia Saeian
Journal:  Am J Gastroenterol       Date:  2007-07-19       Impact factor: 10.864

3.  Hepatic encephalopathy and fitness to drive.

Authors:  Gerald Kircheis; Anja Knoche; Norbert Hilger; Frank Manhart; Alfons Schnitzler; Horst Schulze; Dieter Häussinger
Journal:  Gastroenterology       Date:  2009-08-15       Impact factor: 22.682

4.  Evaluation of neuropsychological function in patients with liver cirrhosis with special reference to their driving ability.

Authors:  A Watanabe; T Tuchida; Y Yata; Y Kuwabara
Journal:  Metab Brain Dis       Date:  1995-09       Impact factor: 3.584

Review 5.  Legal Responsibilities of Physicians When They Diagnose Hepatic Encephalopathy.

Authors:  John M Vierling
Journal:  Clin Liver Dis       Date:  2015-08       Impact factor: 6.126

6.  Subclinical hepatic encephalopathy predicts the development of overt hepatic encephalopathy.

Authors:  M Romero-Gómez; F Boza; M S García-Valdecasas; E García; J Aguilar-Reina
Journal:  Am J Gastroenterol       Date:  2001-09       Impact factor: 10.864

7.  Insight and danger in Alzheimer's disease.

Authors:  S E Starkstein; R Jorge; R Mizrahi; J Adrian; R G Robinson
Journal:  Eur J Neurol       Date:  2007-04       Impact factor: 6.089

8.  Latent portasystemic encephalopathy. I. Nature of cerebral functional defects and their effect on fitness to drive.

Authors:  H Schomerus; W Hamster; H Blunck; U Reinhard; K Mayer; W Dölle
Journal:  Dig Dis Sci       Date:  1981-07       Impact factor: 3.199

9.  Anosognosia in mild cognitive impairment: Relationship to activation of cortical midline structures involved in self-appraisal.

Authors:  Michele L Ries; Britta M Jabbar; Taylor W Schmitz; Mehul A Trivedi; Carey E Gleason; Cynthia M Carlsson; Howard A Rowley; Sanjay Asthana; Sterling C Johnson
Journal:  J Int Neuropsychol Soc       Date:  2007-05       Impact factor: 2.892

10.  In Patients With Cirrhosis, Driving Simulator Performance Is Associated With Real-life Driving.

Authors:  Mette M Lauridsen; Leroy R Thacker; Melanie B White; Ariel Unser; Richard K Sterling; Richard T Stravitz; Scott Matherly; Puneet Puri; Arun J Sanyal; Edith A Gavis; Velimir Luketic; Muhammad S Siddiqui; Douglas M Heuman; Michael Fuchs; Jasmohan S Bajaj
Journal:  Clin Gastroenterol Hepatol       Date:  2015-11-19       Impact factor: 11.382

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  7 in total

1.  Canadian regulations and legal ramifications for hepatic encephalopathy: a descriptive analysis.

Authors:  Henry H Nguyen; Mark G Swain; Philip Wong; Stephen E Congly
Journal:  CMAJ Open       Date:  2018-12-03

2.  Role of Brain Biomarkers S-100-Beta and Neuron-Specific Enolase for Detection and Follow-Up of Hepatic Encephalopathy in Cirrhosis before, during and after Treatment with L-Ornithine-L-Aspartate.

Authors:  Hendrik Strebel; Bernhard Haller; Maximilian Sohn; Wolfgang Schepp; Felix Gundling
Journal:  GE Port J Gastroenterol       Date:  2020-04-21

3.  Hepatic encephalopathy.

Authors:  Peter Ferenci
Journal:  Gastroenterol Rep (Oxf)       Date:  2017-04-18

Review 4.  The Drives for Driving Simulation: A Scientometric Analysis and a Selective Review of Reviews on Simulated Driving Research.

Authors:  Alessandro Oronzo Caffò; Luigi Tinella; Antonella Lopez; Giuseppina Spano; Ylenia Massaro; Andrea Lisi; Fabrizio Stasolla; Roberto Catanesi; Francesco Nardulli; Ignazio Grattagliano; Andrea Bosco
Journal:  Front Psychol       Date:  2020-05-27

5.  Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: a case control study.

Authors:  Masakuni Tateyama; Hideaki Naoe; Motohiko Tanaka; Kentaro Tanaka; Satoshi Narahara; Takayuki Tokunaga; Takeshi Kawasaki; Yoko Yoshimaru; Katsuya Nagaoka; Takehisa Watanabe; Hiroko Setoyama; Yutaka Sasaki; Yasuhito Tanaka
Journal:  BMC Gastroenterol       Date:  2020-11-09       Impact factor: 3.067

6.  Association between serum albumin and cognitive dysfunction in hepatic encephalopathy: An exploratory data analysis.

Authors:  Kosuke Kaji; Kiwamu Okita; Kazuyuki Suzuki; Ikuya Sato; Masaki Fujisawa; Hitoshi Yoshiji
Journal:  JGH Open       Date:  2020-12-07

7.  Hepatic Encephalopathy: A Diagnosis for the Individual but an Experience for the Household.

Authors:  Jeremy Louissaint; Elliot B Tapper
Journal:  Clin Transl Gastroenterol       Date:  2020-05       Impact factor: 4.396

  7 in total

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