Literature DB >> 28026963

Tandem Addition/Cyclization for Access to Isoquinolines and Isoquinolones via Catalytic Carbopalladation of Nitriles.

Linjun Qi1, Kun Hu1, Shuling Yu1, Jianghe Zhu1, Tianxing Cheng1, Xiaodong Wang1, Jiuxi Chen1, Huayue Wu1.   

Abstract

The first example of the palladium-catalyzed sequential nucleophilic addition followed by an intramolecular cyclization of functionalized nitriles with arylboronic acids has been achieved, providing an efficient synthetic pathway to access structurally diverse isoquinolines and isoquinolones. This methodology has also been successfully applied to the total synthesis of the topoisomerase I inhibitor CWJ-a-5 (free base).

Entities:  

Year:  2016        PMID： 28026963     DOI： 10.1021/acs.orglett.6b03499

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Efficient Approach to Carbinol Derivatives through Palladium-Catalyzed Base-Free Addition of Aryltriolborates to Aldehydes.

Authors:  Kun Hu; Pengqing Ye; Qianqian Zhen; Xinrong Yao; Tong Xu; Yinlin Shao; Jiuxi Chen
Journal:  Molecules       Date:  2017-09-20       Impact factor: 4.411

2.  Efficient Tandem Addition/Cyclization for Access to 2,4-Diarylquinazolines via Catalytic Carbopalladation of Nitriles.

Authors:  Julin Gong; Kun Hu; Yetong Zhang; Yinlin Shao; Tianxing Cheng; Maolin Hu; Jiuxi Chen
Journal:  Molecules       Date:  2019-01-28       Impact factor: 4.411

3.  Efficient synthesis of spirooxindolyl oxazol-2(5H)-ones via palladium(ii)-catalyzed addition of arylboronic acids to nitriles.

Authors:  Hao Song; Na Cheng; Li-Qin She; Yi Wu; Wei-Wei Liao
Journal:  RSC Adv       Date:  2019-09-17       Impact factor: 4.036

4.  The synthesis of quinolines via denitrogenative palladium-catalyzed cascade reaction of o-aminocinnamonitriles with arylhydrazines.

Authors:  Jing Xie; Hang Huang; Tong Xu; Renhao Li; Jiuxi Chen; Xueting Ye
Journal:  RSC Adv       Date:  2020-03-03       Impact factor: 4.036

5.  Palladium-catalyzed tandem allylic substitution/cyclization and cascade hydrosilylated reduction: the influence of reaction parameters and hydrosilanes on the stereoselectivity.

Authors:  Peng-Wei Long; Jian-Xing Xu; Xing-Feng Bai; Zheng Xu; Zhan-Jiang Zheng; Ke-Fang Yang; Li Li; Li-Wen Xu
Journal:  RSC Adv       Date:  2018-06-22       Impact factor: 3.361

6.  Synthesis of Pyrrolo[2,3-c]isoquinolines via the Cycloaddition of Benzyne with Arylideneaminopyrroles: Photophysical and Crystallographic Study.

Authors:  Juan-Carlos Castillo; Alexis Tigreros; Yoann Coquerel; Jean Rodríguez; Mario A Macías; Jaime Portilla
Journal:  ACS Omega       Date:  2019-10-09
  6 in total

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