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Literature DB >> 28026129

Light-Enhancing Plasmonic-Nanopore Biosensor for Superior Single-Molecule Detection.

Ossama N Assad^1,2, Tal Gilboa¹, Joshua Spitzberg¹, Matyas Juhasz³, Elmar Weinhold³, Amit Meller^1,2.

Abstract

A stacked plasmonic nanowell-nanopore biosensor strongly suppresses the background fluorescence from the bulk and yields net more than tenfold enhancement of the fluorescence intensity. The device offers extremely high signal-to-background (S/B) ratio for single-molecule detection at ultralow excitation laser intensities, while maintaining extremely high temporal bandwidth for single-DNA sensing.

Keywords: DNA sequencing; fluorescence enhancement; plasmonic nanostructures; single-molecule sensing; solid-state nanopores

Mesh：

Substances：
DNA

Year: 2016 PMID： 28026129 DOI： 10.1002/adma.201605442

Source DB: PubMed Journal: Adv Mater ISSN： 0935-9648 Impact factor: 30.849

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Cited

15 in total

1. Nanoparticle-blockage-enabled rapid and reversible nanopore gating with tunable memory.

Authors: Rami Yazbeck; Yixin Xu; Tyrone Porter; Chuanhua Duan
Journal: Proc Natl Acad Sci U S A Date: 2022-06-27 Impact factor: 12.779

Review 2. Localized Nanopore Fabrication via Controlled Breakdown.

Authors: Cuifeng Ying; Tianji Ma; Lei Xu; Mohsen Rahmani
Journal: Nanomaterials (Basel) Date: 2022-07-12 Impact factor: 5.719

3. Self-Induced Back-Action Actuated Nanopore Electrophoresis (SANE) Sensor for Label-Free Detection of Cancer Immunotherapy-Relevant Antibody-Ligand Interactions.

Authors: Sai Santosh Sasank Peri; Muhammad Usman Raza; Manoj K Sabnani; Soroush Ghaffari; Susanne Gimlin; Debra D Wawro; Jung Soo Lee; Min Jun Kim; Jon Weidanz; George Alexandrakis
Journal: Methods Mol Biol Date: 2022

4. Nanopore Fabrication and Application as Biosensors in Neurodegenerative Diseases.

Authors: Brian Lenhart; Xiaojun Wei; Zehui Zhang; Xiaoqin Wang; Qian Wang; Chang Liu
Journal: Crit Rev Biomed Eng Date: 2020

Review 5. Advanced Nanoscale Approaches to Single-(Bio)entity Sensing and Imaging.

Authors: Marta Maria Pereira da Silva Neves; Daniel Martín-Yerga
Journal: Biosensors (Basel) Date: 2018-10-26

Review 6. The emerging landscape of single-molecule protein sequencing technologies.

Authors: Javier Antonio Alfaro; Peggy Bohländer; Mingjie Dai; Mike Filius; Cecil J Howard; Xander F van Kooten; Shilo Ohayon; Adam Pomorski; Sonja Schmid; Amit Meller; Chirlmin Joo; Aleksei Aksimentiev; Eric V Anslyn; Georges Bedran; Chan Cao; Mauro Chinappi; Etienne Coyaud; Cees Dekker; Gunnar Dittmar; Nicholas Drachman; Rienk Eelkema; David Goodlett; Sébastien Hentz; Umesh Kalathiya; Neil L Kelleher; Ryan T Kelly; Zvi Kelman; Sung Hyun Kim; Bernhard Kuster; David Rodriguez-Larrea; Stuart Lindsay; Giovanni Maglia; Edward M Marcotte; John P Marino; Christophe Masselon; Michael Mayer; Patroklos Samaras; Kumar Sarthak; Lusia Sepiashvili; Derek Stein; Meni Wanunu; Mathias Wilhelm; Peng Yin
Journal: Nat Methods Date: 2021-06-07 Impact factor: 47.990

Light-Enhancing Plasmonic-Nanopore Biosensor for Superior Single-Molecule Detection.

1. Nanoparticle-blockage-enabled rapid and reversible nanopore gating with tunable memory.

Review 2. Localized Nanopore Fabrication via Controlled Breakdown.

3. Self-Induced Back-Action Actuated Nanopore Electrophoresis (SANE) Sensor for Label-Free Detection of Cancer Immunotherapy-Relevant Antibody-Ligand Interactions.

4. Nanopore Fabrication and Application as Biosensors in Neurodegenerative Diseases.

Review 5. Advanced Nanoscale Approaches to Single-(Bio)entity Sensing and Imaging.

Review 6. The emerging landscape of single-molecule protein sequencing technologies.

7. Active Delivery of Single DNA Molecules into a Plasmonic Nanopore for Label-Free Optical Sensing.

8. Small molecule electro-optical binding assay using nanopores.

9. Simulation of single-protein nanopore sensing shows feasibility for whole-proteome identification.

Review 10. Microfluidic Systems Applied in Solid-State Nanopore Sensors.