Ana Bagüés1, M Isabel Martín-Fontelles1, Jesús Esteban-Hernández2, Eva M Sánchez-Robles1. 1. Área de Farmacología y Nutrición, Unidad asociada I+D+i al Instituto de Química Médica, Grupo de excelencia investigadora URJC-Banco de Santander-Grupo Multidisciplinar de Investigación y Tratamiento del Dolor (i+DOL), Alcorcón, Madrid, Spain. 2. Área de Medicina Preventiva y Salud Pública, Facultad de Ciencias de la Salud. Universidad Rey Juan Carlos, Alcorcón, Madrid, Spain.
Abstract
INTRODUCTION: To better understand the pathophysiology of chronic muscle pain, there are multiple animal models that mimic different acute/chronic pain conditions, such as carrageenan injection. Our previous studies demonstrated differences between muscles of different innervation in acute pain. In this study we characterized the effect of carrageenan in 2 muscles: masseter (trigeminal innervation) and gastrocnemius (spinal innervation). METHODS: Carrageenan (3%, 6%, and 9%) was injected into the masseter and gastrocnemius of rats. Mechanical, heat, and chemical nociceptive thresholds were measured for 14 days. RESULTS: Carrageenan did not induce mechanical allodynia or thermal hypersensitivity in either muscle. Instead, it induced a short-lasting mechanical hyperalgesia, greater in the masseter than in the gastrocnemius. CONCLUSION: Carrageenan injected into the masseter and gastrocnemius induces a short-lasting hyperalgesia. These results could indicate a higher susceptibility of orofacial muscles to this type of insult and, consequently, a difference between trigeminal and spinal innervation. Muscle Nerve 56: 804-813, 2017.
INTRODUCTION: To better understand the pathophysiology of chronic muscle pain, there are multiple animal models that mimic different acute/chronic pain conditions, such as carrageenan injection. Our previous studies demonstrated differences between muscles of different innervation in acute pain. In this study we characterized the effect of carrageenan in 2 muscles: masseter (trigeminal innervation) and gastrocnemius (spinal innervation). METHODS:Carrageenan (3%, 6%, and 9%) was injected into the masseter and gastrocnemius of rats. Mechanical, heat, and chemical nociceptive thresholds were measured for 14 days. RESULTS:Carrageenan did not induce mechanical allodynia or thermal hypersensitivity in either muscle. Instead, it induced a short-lasting mechanical hyperalgesia, greater in the masseter than in the gastrocnemius. CONCLUSION:Carrageenan injected into the masseter and gastrocnemius induces a short-lasting hyperalgesia. These results could indicate a higher susceptibility of orofacial muscles to this type of insult and, consequently, a difference between trigeminal and spinal innervation. Muscle Nerve 56: 804-813, 2017.
Authors: Janaíne P Oliveira; Fabíula F Abreu; José Marcos M Bispo; Anderson R A Cerqueira; José Ronaldo Dos Santos; Cristiane B Correa; Soraia K P Costa; Enilton A Camargo Journal: Front Pharmacol Date: 2022-05-30 Impact factor: 5.988
Authors: Damian Jacenik; Ana Bagüés; Laura López-Gómez; Yolanda López-Tofiño; Amaia Iriondo-DeHond; Cristina Serra; Laura Banovcanová; Carlos Gálvez-Robleño; Jakub Fichna; Maria Dolores Del Castillo; José Antonio Uranga; Raquel Abalo Journal: Nutrients Date: 2021-05-30 Impact factor: 5.717