Ji Hyung Nam1, Chang Won Hong2,3, Byung Chang Kim1,4, Aesun Shin5,6, Kum Hei Ryu1, Bum Joon Park1, Bun Kim1,4, Dae Kyung Sohn1,4, Kyung Su Han1,4, Jeongseon Kim6, Chan Wha Lee1. 1. Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea. 2. Center for Cancer Prevention and Detection, National Cancer Center, Goyang-si, Republic of Korea. hong@ncc.re.kr. 3. Center for Colorectal Cancer, National Cancer Center, Goyang-si, Republic of Korea. hong@ncc.re.kr. 4. Center for Colorectal Cancer, National Cancer Center, Goyang-si, Republic of Korea. 5. Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. 6. Molecular Epidemiology Branch, Research Institute, National Cancer Center, Goyang-si, Republic of Korea.
Abstract
PURPOSE: Helicobacter pylori infection is considered to have a positive association with colorectal neoplasms. In this study, we evaluated the association between H. pylori infection and colorectal adenomas, based on the characteristics of these adenomas in Korea, where the prevalence of H. pylori infection is high and the incidence of colorectal cancer continues to increase. METHODS: The study cohort consisted of 4,466 subjects who underwent colonoscopy and esophagogastroduodenoscopy during screening (1,245 colorectal adenomas vs. 3,221 polyp-free controls). We compared the rate of H. pylori infection between patients with adenoma and polyp-free control cases, using multivariable logistic regression analysis. RESULTS: The overall rate of positive H. pylori infection was higher in adenoma cases than in polyp-free control cases (55.0 vs. 48.5%, p < 0.001). The odds ratio (OR) of positive H. pylori infection in patients with adenoma compared to polyp-free controls was 1.28 (95% CI 1.11-1.47). The positive association of H. pylori infection with colorectal adenomas was more prominent in advanced adenomas (OR 1.84, 95% CI 1.25-2.70) and multiple adenomas (OR 1.72, 95% CI 1.26-2.35). Based on the location of these adenomas, the OR was significant only in patients with colonic adenomas (OR 1.31, 95% CI 1.13-1.52) and not in those with rectal adenoma (OR 0.85, 95% CI 0.58-1.24). CONCLUSION: Helicobacter pylori infection is an independent risk factor for colonic adenomas, especially in cases of advanced or multiple adenomas, but not for rectal adenomas.
PURPOSE:Helicobacter pyloriinfection is considered to have a positive association with colorectal neoplasms. In this study, we evaluated the association between H. pyloriinfection and colorectal adenomas, based on the characteristics of these adenomas in Korea, where the prevalence of H. pyloriinfection is high and the incidence of colorectal cancer continues to increase. METHODS: The study cohort consisted of 4,466 subjects who underwent colonoscopy and esophagogastroduodenoscopy during screening (1,245 colorectal adenomas vs. 3,221 polyp-free controls). We compared the rate of H. pyloriinfection between patients with adenoma and polyp-free control cases, using multivariable logistic regression analysis. RESULTS: The overall rate of positive H. pyloriinfection was higher in adenoma cases than in polyp-free control cases (55.0 vs. 48.5%, p < 0.001). The odds ratio (OR) of positive H. pyloriinfection in patients with adenoma compared to polyp-free controls was 1.28 (95% CI 1.11-1.47). The positive association of H. pyloriinfection with colorectal adenomas was more prominent in advanced adenomas (OR 1.84, 95% CI 1.25-2.70) and multiple adenomas (OR 1.72, 95% CI 1.26-2.35). Based on the location of these adenomas, the OR was significant only in patients with colonic adenomas (OR 1.31, 95% CI 1.13-1.52) and not in those with rectal adenoma (OR 0.85, 95% CI 0.58-1.24). CONCLUSION:Helicobacter pyloriinfection is an independent risk factor for colonic adenomas, especially in cases of advanced or multiple adenomas, but not for rectal adenomas.
Entities:
Keywords:
Adenoma; Colonoscopy; H. Pylori; Risk factor
Authors: Marta Mangifesta; Leonardo Mancabelli; Christian Milani; Federica Gaiani; Nicola de'Angelis; Gian Luigi de'Angelis; Douwe van Sinderen; Marco Ventura; Francesca Turroni Journal: Sci Rep Date: 2018-09-18 Impact factor: 4.379