Literature DB >> 2802532

Increased replication of HTLV-I in HTLV-I-associated myelopathy.

M Yoshida1, M Osame, H Kawai, M Toita, N Kuwasaki, Y Nishida, Y Hiraki, K Takahashi, K Nomura, S Sonoda.   

Abstract

To estimate the replication of the human T-cell leukemia virus type I (HTLV-I) in patients with HTLV-I-associated myelopathy (HAM), or tropical spastic paraparesis (TSP), HTLV-I DNA integrated into lymphocyte genomes was analyzed by Southern blot hybridization. HTLV-I DNA was detected in 125 (82%) of 153 patients and most showed random integration. This incidence was much higher than the 29% found in asymptomatic carriers. Therefore, HAM/TSP development is associated with a high level of HTLV-I replication. In addition, lymphocytes from 3 patients with HAM/TSP showed monoclonal integration of HTLV-I DNA, indicating adult T-cell leukemia.

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Year:  1989        PMID： 2802532     DOI： 10.1002/ana.410260304

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  44 in total

1.  HTLV-I proviral load correlates with progression of motor disability in HAM/TSP: analysis of 239 HAM/TSP patients including 64 patients followed up for 10 years.

Authors:  T Matsuzaki; M Nakagawa; M Nagai; K Usuku; I Higuchi; K Arimura; H Kubota; S Izumo; S Akiba; M Osame
Journal:  J Neurovirol       Date:  2001-06       Impact factor: 2.643

Review 2.  HTLV-1 infections.

Authors:  C R Bangham
Journal:  J Clin Pathol       Date:  2000-08       Impact factor: 3.411

3.  Development of human T-cell leukemia virus type 1-transformed tumors in rats following suppression of T-cell immunity by CD80 and CD86 blockade.

Authors:  S Hanabuchi; T Ohashi; Y Koya; H Kato; F Takemura; K Hirokawa; T Yoshiki; H Yagita; K Okumura; M Kannagi
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

4.  A tax on luxury: HTLV-I infection of CD4+CD25+ Tregs.

Authors:  Robert S Fujinami
Journal:  J Clin Invest       Date:  2005-05       Impact factor: 14.808

5.  Search for human T-cell leukemia virus type I (HTLV-I) proviral sequences by polymerase chain reaction in the central nervous system tissue of HTLV-I-associated myelopathy.

Authors:  Y Ohara; Y Iwasaki; S Izumo; I Kobayashi; A Yoshioka
Journal:  Arch Virol       Date:  1992       Impact factor: 2.574

Review 6.  Human T-lymphotropic virus type 1 (HTLV-1): persistence and immune control.

Authors:  Charles R M Bangham
Journal:  Int J Hematol       Date:  2003-11       Impact factor: 2.490

7.  Clonal expansion of CD8+ cytotoxic T lymphocytes against human T cell lymphotropic virus type I (HTLV-I) genome products in HTLV-I-associated myelopathy/tropical spastic paraparesis patients.

Authors:  K Furukawa; M Mori; N Ohta; H Ikeda; H Shida; K Furukawa; H Shiku
Journal:  J Clin Invest       Date:  1994-11       Impact factor: 14.808

8.  Clonal expansion of human T-cell leukemia virus type I-infected cells in asymptomatic and symptomatic carriers without malignancy.

Authors:  E Wattel; J P Vartanian; C Pannetier; S Wain-Hobson
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

9.  Increased number of circulating HTLV-1 infected cells in peripheral blood mononuclear cells of HTLV-1 uveitis patients: a quantitative polymerase chain reaction study.

Authors:  A Ono; M Mochizuki; K Yamaguchi; N Miyata; T Watanabe
Journal:  Br J Ophthalmol       Date:  1995-03       Impact factor: 4.638

Review 10.  Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management.

Authors:  Sue Lim; Kevin Katz; Sigmund Krajden; Milan Fuksa; Jay S Keystone; Kevin C Kain
Journal:  CMAJ       Date:  2004-08-31       Impact factor: 8.262
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