Paul Ritvo1, Ronald E Myers2, Mardie Serenity3, Samir Gupta4, John M Inadomi5, Beverly B Green6, Anthony Jerant7, Jill Tinmouth8, Lawrence Paszat9, Meysam Pirbaglou10, Linda Rabeneck11. 1. York University, Kinesiology and Health Science, 4700 Keele St., Toronto, ON CAN M3J 1P3, Canada; Ontario Cancer Institute, Division of Epidemiology and Biostatistics, 600 University Ave., Toronto, ON CAN M5G2C4, Canada. Electronic address: pritvo@yorku.ca. 2. Thomas Jefferson University, Medical Oncology, 834 Chestnut Street, Suite 413, Philadelphia, PA, USA. Electronic address: ronald.myers@jefferson.edu. 3. Sunnybrook Health Sciences Centre, Clinical Epidemiology, Toronto, ON, Canada. Electronic address: mardie.serenity@sunnybrook.ca. 4. San Diego Veterans Affairs Healthcare System, Department of Medicine, Section of Gastroenterology, 3350 La Jolla Village Dr, MC 111D San Diego, CA, USA. Electronic address: s1gupta@ucsd.edu. 5. Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, WA, USA. Electronic address: JInadomi@medicine.washington.edu. 6. Group Health Cooperative, Group Health Research Institute, Seattle, WA, USA. Electronic address: green.b@ghc.org. 7. UC Davis, Department of Family Medicine, Sacramento, CA, USA. Electronic address: afjerant@ucdavis.edu. 8. Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Room: HG40, Toronto, ON, Canada. Electronic address: jill.tinmouth@sunnybrook.ca. 9. University of Toronto, Institute of Health Policy, Management & Evaluation, Toronto, ON, Canada; Institute for Clinical Evaluative Sciences, Toronto, ON, Canada. Electronic address: Lawrence@ices.on.ca. 10. York University, Kinesiology and Health Science, 4700 Keele St., Toronto, ON CAN M3J 1P3, Canada. Electronic address: meyir@yorku.ca. 11. Cancer Care Ontario, Prevention and Cancer Control, Toronto, ON, Canada. Electronic address: Linda.Rabeneck@cancercare.on.ca.
Abstract
OBJECTIVE: To derive a taxonomy for colorectal cancer screening that advances Randomized Controlled Trials (RCTs) and screening uptake. DESIGN: Detailed publication review, multiple interviews with principal investigators (PIs) and collaboration with PIs as co-authors produced a CRCS intervention taxonomy. Semi-structured interview questions with PIs (Drs. Inadomi, Myers, Green, Gupta, Jerant and Ritvo) yielded details about trial conduct. Interview comparisons led to an iterative process informing serial interviews until a consensus was obtained on final taxonomy structure. RESULTS: These taxonomy headings (Engagement Sponsor, Population Targeted, Alternative Screening Tests, Delivery Methods, and Support for Test Performance (EPADS)) were used to compare studies. Exemplary insights emphasized: 1) direct test delivery to patients; 2) linguistic-ethnic matching of staff to minority subjects; and 3) authorization of navigators to schedule or refer for colonoscopies and/or distribute stool blood tests during screening promotion. CONCLUSION: PIs of key RCTs (2012-2015) derived a CRCS taxonomy useful in detailed examination of CRCS promotion and design of future RCTs.
OBJECTIVE: To derive a taxonomy for colorectal cancer screening that advances Randomized Controlled Trials (RCTs) and screening uptake. DESIGN: Detailed publication review, multiple interviews with principal investigators (PIs) and collaboration with PIs as co-authors produced a CRCS intervention taxonomy. Semi-structured interview questions with PIs (Drs. Inadomi, Myers, Green, Gupta, Jerant and Ritvo) yielded details about trial conduct. Interview comparisons led to an iterative process informing serial interviews until a consensus was obtained on final taxonomy structure. RESULTS: These taxonomy headings (Engagement Sponsor, Population Targeted, Alternative Screening Tests, Delivery Methods, and Support for Test Performance (EPADS)) were used to compare studies. Exemplary insights emphasized: 1) direct test delivery to patients; 2) linguistic-ethnic matching of staff to minority subjects; and 3) authorization of navigators to schedule or refer for colonoscopies and/or distribute stool blood tests during screening promotion. CONCLUSION:PIs of key RCTs (2012-2015) derived a CRCS taxonomy useful in detailed examination of CRCS promotion and design of future RCTs.
Authors: Melinda M Davis; Michele Freeman; Jackilen Shannon; Gloria D Coronado; Kurt C Stange; Jeanne-Marie Guise; Stephanie B Wheeler; David I Buckley Journal: BMC Cancer Date: 2018-01-06 Impact factor: 4.430