Literature DB >> 28019641

Green Synthesis and Molecular Docking of Thiazolyl-thiazole Derivatives as Potential Cytotoxic Agents.

Sobhi M Gomha1, Mohamad R Abdelaziz2, Hassan M Abdel-Aziz3, Shaimaa A Hassan1.   

Abstract

METHOD: A series of novel thiazole derivatives were synthesized in a good yield via reaction of 2-(1-(4-methyl-2-phenylthiazol-5-yl)ethylidene)hydrazine carbothioamide with hydrazonoyl halides. The reaction was performed in the presence of DABCO as an organocatalyst in short reaction times, easy workup, good to excellent yields. The structure of the newly synthesized products was elucidated via elemental analysis, spectral data and alternative routes whenever possible. Ten compounds were evaluated for their anti-cancer activity against the colon carcinoma cell line (HCT-116). RESULTS &
CONCLUSION: The results revealed that most of the tested compounds showed high or moderate anti-cancer activity. The molecular docking of five novel thiazolyl-thiazole derivatives was performed by the Molecular Operating Environment (MOE) program. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Cytotoxic activity; hydrazonoyl halides; molecular docking; tautomerism; thiazoles; thiosemicarbazone

Mesh：

Substances：

Year:  2017        PMID： 28019641     DOI： 10.2174/1389557516666161223154539

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  5 in total

1.  A facile access and evaluation of some novel thiazole and 1,3,4-thiadiazole derivatives incorporating thiazole moiety as potent anticancer agents.

Authors:  Sobhi M Gomha; Mohamad R Abdelaziz; Nabila A Kheder; Hassan M Abdel-Aziz; Seham Alterary; Yahia N Mabkhot
Journal:  Chem Cent J       Date:  2017-10-16       Impact factor: 4.215

2.  Utility of 2-thioxo-pyrido[2,3-d]pyrimidinone in synthesis of pyridopyrimido[2,1-b][1,3,5]-thiadiazinones and pyridopyrimido[2,1-b][1,3]thiazinones as antimicrobial agents.

Authors:  Yasser H Zaki; Sobhi M Gomha; Amany M G Mohamed
Journal:  Chem Cent J       Date:  2017-06-20       Impact factor: 4.215

3.  Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents.

Authors:  Latifah A Alshabanah; Laila A Al-Mutabagani; Sobhi M Gomha; Hoda A Ahmed
Journal:  Front Chem       Date:  2022-01-25       Impact factor: 5.221

4.  Evaluation of the Binding Relationship of the RdRp Enzyme to Novel Thiazole/Acid Hydrazone Hybrids Obtainable through Green Synthetic Procedure.

Authors:  Jehan Y Al-Humaidi; Mohamed G Badrey; Ashraf A Aly; AbdElAziz A Nayl; Mohie E M Zayed; Ohoud A Jefri; Sobhi M Gomha
Journal:  Polymers (Basel)       Date:  2022-08-03       Impact factor: 4.967

5.  Synthesis and Biological Evaluation of Thiazole-Based Derivatives with Potential against Breast Cancer and Antimicrobial Agents.

Authors:  Ekaterina Pivovarova; Alina Climova; Marcin Świątkowski; Marek Staszewski; Krzysztof Walczyński; Marek Dzięgielewski; Marta Bauer; Wojciech Kamysz; Anna Krześlak; Paweł Jóźwiak; Agnieszka Czylkowska
Journal:  Int J Mol Sci       Date:  2022-08-30       Impact factor: 6.208
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.