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Literature DB >> 28018580

Engineering of Brome mosaic virus for biomedical applications.

Ibrahim Yildiz¹, Irina Tsvetkova², Amy M Wen¹, Sourabh Shukla¹, M Hema Masarapu², Bogdan Dragnea², Nicole F Steinmetz³.

Abstract

Viral nanoparticles (VNPs) are becoming versatile tools in platform technology development. Their well-defined structures as well as their programmability through chemical and genetic modification allow VNPs to be engineered for potential imaging and therapeutic applications. In this article, we report the application of a variety of bioconjugation chemistries to the plant VNP Brome mosaic virus (BMV). Functional BMV nanoparticles displaying multiple copies of fluorescent dyes, PEG molecules, chemotherapeutic drug moieties, targeting proteins and cell penetrating peptides were formulated. This opens the door for the application of BMV in nanomedicine.

Entities: Chemical Disease Gene Species

Year: 2012 PMID： 28018580 PMCID： PMC5180450 DOI： 10.1039/C2RA01376B

Source DB: PubMed Journal: RSC Adv ISSN： 2046-2069 Impact factor: 3.361

41 in total

1. Dual-surface-modified bacteriophage MS2 as an ideal scaffold for a viral capsid-based drug delivery system.

Authors: Ernest W Kovacs; Jacob M Hooker; Dante W Romanini; Patrick G Holder; Katherine E Berry; Matthew B Francis
Journal: Bioconjug Chem Date: 2007-06-30 Impact factor: 4.774

2. Role of surface charge density in nanoparticle-templated assembly of bromovirus protein cages.

Authors: Marie-Christine Daniel; Irina B Tsvetkova; Zachary T Quinkert; Ayaluru Murali; Mrinmoy De; Vincent M Rotello; C Cheng Kao; Bogdan Dragnea
Journal: ACS Nano Date: 2010-07-27 Impact factor: 15.881

3. Decoration of discretely immobilized cowpea mosaic virus with luminescent quantum dots.

Authors: Igor L Medintz; Kim E Sapsford; John H Konnert; Anju Chatterji; Tianwei Lin; John E Johnson; Hedi Mattoussi
Journal: Langmuir Date: 2005-06-07 Impact factor: 3.882

4. Quantum dot encapsulation in viral capsids.

Authors: Suraj K Dixit; Nancy L Goicochea; Marie-Christine Daniel; Ayaluru Murali; Lyudmila Bronstein; Mrinmoy De; Barry Stein; Vincent M Rotello; C Cheng Kao; Bogdan Dragnea
Journal: Nano Lett Date: 2006-09 Impact factor: 11.189

5. A virus-based nanoblock with tunable electrostatic properties.

Authors: Anju Chatterji; Wendy F Ochoa; Takafumi Ueno; Tianwei Lin; John E Johnson
Journal: Nano Lett Date: 2005-04 Impact factor: 11.189

6. Cowpea mosaic virus nanoparticles target surface vimentin on cancer cells.

Authors: Nicole F Steinmetz; Choi-Fong Cho; Amber Ablack; John D Lewis; Marianne Manchester
Journal: Nanomedicine (Lond) Date: 2011-02 Impact factor: 5.307

7. Intravital imaging of human prostate cancer using viral nanoparticles targeted to gastrin-releasing Peptide receptors.

Authors: Nicole F Steinmetz; Amber L Ablack; Jennifer L Hickey; Jailal Ablack; Bhavik Manocha; Joe S Mymryk; Leonard G Luyt; John D Lewis
Journal: Small Date: 2011-04-26 Impact factor: 13.281

8. PEGylated viral nanoparticles for biomedicine: the impact of PEG chain length on VNP cell interactions in vitro and ex vivo.

Authors: Nicole F Steinmetz; Marianne Manchester
Journal: Biomacromolecules Date: 2009-04-13 Impact factor: 6.988

9. Folic acid-mediated targeting of cowpea mosaic virus particles to tumor cells.

Authors: Giuseppe Destito; Robert Yeh; Chris S Rae; M G Finn; Marianne Manchester
Journal: Chem Biol Date: 2007-10

10. Bio-distribution, toxicity and pathology of cowpea mosaic virus nanoparticles in vivo.

Authors: Pratik Singh; Duane Prasuhn; Robert M Yeh; Giuseppe Destito; Chris S Rae; Kent Osborn; M G Finn; Marianne Manchester
Journal: J Control Release Date: 2007-04-13 Impact factor: 9.776

12 in total

1. A plant derived multifunctional tool for nanobiotechnology based on Tomato bushy stunt virus.

Authors: Simone Grasso; Chiara Lico; Francesca Imperatori; Luca Santi
Journal: Transgenic Res Date: 2012-10-30 Impact factor: 2.788

Review 2. Strategies for delivering therapeutics across the blood-brain barrier.

Authors: Georg C Terstappen; Axel H Meyer; Robert D Bell; Wandong Zhang
Journal: Nat Rev Drug Discov Date: 2021-03-01 Impact factor: 84.694

3. Virus-Mimicking Nanoparticles for Targeted Near Infrared Fluorescence Imaging of Intraperitoneal Ovarian Tumors in Mice.

Authors: Raviraj Vankayala; Edver Bahena; Yadir Guerrero; Sheela P Singh; Murali K Ravoori; Vikas Kundra; Bahman Anvari
Journal: Ann Biomed Eng Date: 2020-08-06 Impact factor: 3.934

Engineering of Brome mosaic virus for biomedical applications.

1. Dual-surface-modified bacteriophage MS2 as an ideal scaffold for a viral capsid-based drug delivery system.

2. Role of surface charge density in nanoparticle-templated assembly of bromovirus protein cages.

3. Decoration of discretely immobilized cowpea mosaic virus with luminescent quantum dots.

4. Quantum dot encapsulation in viral capsids.

5. A virus-based nanoblock with tunable electrostatic properties.

6. Cowpea mosaic virus nanoparticles target surface vimentin on cancer cells.

7. Intravital imaging of human prostate cancer using viral nanoparticles targeted to gastrin-releasing Peptide receptors.

8. PEGylated viral nanoparticles for biomedicine: the impact of PEG chain length on VNP cell interactions in vitro and ex vivo.

9. Folic acid-mediated targeting of cowpea mosaic virus particles to tumor cells.

10. Bio-distribution, toxicity and pathology of cowpea mosaic virus nanoparticles in vivo.

1. A plant derived multifunctional tool for nanobiotechnology based on Tomato bushy stunt virus.

Review 2. Strategies for delivering therapeutics across the blood-brain barrier.

3. Virus-Mimicking Nanoparticles for Targeted Near Infrared Fluorescence Imaging of Intraperitoneal Ovarian Tumors in Mice.

4. Viral nanoparticles for in vivo tumor imaging.

5. Subset of Fluorophores Is Responsible for Radiation Brightening in Viromimetic Particles.

Review 6. Virus-like particles: Next-generation nanoparticles for targeted therapeutic delivery.

7. Perspective: Solidifying the impact of cell-free synthetic biology through lyophilization.

8. Role of metallic core for the stability of virus-like particles in strongly coupled electrostatics.

Review 9. Application of Plant Viruses as a Biotemplate for Nanomaterial Fabrication.

Review 10. Plant/Bacterial Virus-Based Drug Discovery, Drug Delivery, and Therapeutics.