Mahmood Moosazadeh1, Zatollah Asemi2, Kamran B Lankarani3, Reza Tabrizi3, Najmeh Maharlouei3, Ahmad Naghibzadeh-Tahami4, Gholamreza Yousefzadeh5, Reza Sadeghi6, Seyed Reza Khatibi7, Mahdi Afshari8, Mahmoud Khodadost9, Maryam Akbari10. 1. Health Sciences Research Center, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran. 2. Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran. 3. Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 4. Physiology Research Center, Institute of Neuropharmacology,Kerman University of Medical Sciences, Kerman, Iran. 5. Cardiovascular Research Center, Institute of Neuropharmacology, Kerman, Iran. 6. Shahid Sadoughi University of Medical Sciences, Yazd, Iran. 7. Torbat Heydariyeh University of Medical Sciences Torbat Heydariyeh, Iran. 8. Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran. 9. Gastroenterology and Liver Diseases Research Center, Baqiyatallah University of Medical Science, Tehran, Iran. 10. Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: M.akbari45@yahoo.com.
Abstract
OBJECTIVE: Gestational diabetes is the most prevalent metabolic disorder being firstly diagnosed during pregnancy. The relationship between the family history of diabetes and the gestational diabetes mellitus (GDM) has been investigated in several primary studies with a number of contradictions in the results. Hence, the purpose of the present study is to determine the relationship between the GDM and the family history of diabetes using the meta-analysis method. METHOD: All published papers in main national and international databases were systematically searched with some specific keywords to find the related studies between 2000 and 2016. We calculated the odds ratio (OR) with 95% confidence interval (CI) in analysis for each study using a random-effect and Mantel-Haenzel method. We also determined heterogeneity among these 33 articles and their publication bias. RESULTS: We entered 33 relevant studies of 2516 articles into the meta-analysis process including 2697 women with family history of diabetes mellitus as well as 29134 women without. Of them, 954 and 4372 subjects developed GDM respectively. Combining the results of the primary studies using the meta-analysis method, the overall odds ratio of family history for developing GDM was estimated as of 3.46 (95% CI: 2.80-4.27). CONCLUSION: This meta-analysis study revealed that the family history of diabetes is an important risk factor for the gestational diabetes mellitus.
OBJECTIVE:Gestational diabetes is the most prevalent metabolic disorder being firstly diagnosed during pregnancy. The relationship between the family history of diabetes and the gestational diabetes mellitus (GDM) has been investigated in several primary studies with a number of contradictions in the results. Hence, the purpose of the present study is to determine the relationship between the GDM and the family history of diabetes using the meta-analysis method. METHOD: All published papers in main national and international databases were systematically searched with some specific keywords to find the related studies between 2000 and 2016. We calculated the odds ratio (OR) with 95% confidence interval (CI) in analysis for each study using a random-effect and Mantel-Haenzel method. We also determined heterogeneity among these 33 articles and their publication bias. RESULTS: We entered 33 relevant studies of 2516 articles into the meta-analysis process including 2697 women with family history of diabetes mellitus as well as 29134 women without. Of them, 954 and 4372 subjects developed GDM respectively. Combining the results of the primary studies using the meta-analysis method, the overall odds ratio of family history for developing GDM was estimated as of 3.46 (95% CI: 2.80-4.27). CONCLUSION: This meta-analysis study revealed that the family history of diabetes is an important risk factor for the gestational diabetes mellitus.
Authors: Feng-Yi Yuan; Min Zhang; Ping Xu; Dan Xu; Ping Chen; Min Ren; Qin Sun; Jing-Yan Chen; Juan Du; Xia-Lian Tang Journal: Exp Ther Med Date: 2018-09-03 Impact factor: 2.447