Reem M Al Haj Ahmad1, Hayder A Al-Domi2. 1. Department of Nutrition and Food Technology, Faculty of Agriculture, The University of Jordan, Queen Rania Street, Amman 11942, Jordan. Electronic address: alhaj.reem@hotmail.com. 2. Department of Nutrition and Food Technology, Faculty of Agriculture, The University of Jordan, Queen Rania Street, Amman 11942, Jordan. Electronic address: h.aldomi@ju.edu.jo.
Abstract
INTRODUCTION: Obesity is frequently characterized by chronic inflammation and insulin resistance (IR). Obesity-associated inflammation is responsible for the complement system activation of which the third component (C3) plays the central role. OBJECTIVE: to discuss several aspects of the central component of the complement system in relation to obesity and obesity-associated IR. METHODS: A critical review of the relevant published English articles from 2003- 2014 was carried out using several search engines including PubMed, Google Scholar, and ScienceDirect. Keywords were used, including complement system, C3, obesity-induced inflammation, IR, ASP, and adipose tissue. CONCLUSION: The defect in the adipose tissue secretory function during obesity may result in different metabolic disorders including IR. The C3 role during obesity-associated inflammation in IR is emerging. More longitudinal studies are warranted to evaluate the role of C3 among other pro-inflammatory biomarkers for IR.
INTRODUCTION:Obesity is frequently characterized by chronic inflammation and insulin resistance (IR). Obesity-associated inflammation is responsible for the complement system activation of which the third component (C3) plays the central role. OBJECTIVE: to discuss several aspects of the central component of the complement system in relation to obesity and obesity-associated IR. METHODS: A critical review of the relevant published English articles from 2003- 2014 was carried out using several search engines including PubMed, Google Scholar, and ScienceDirect. Keywords were used, including complement system, C3, obesity-induced inflammation, IR, ASP, and adipose tissue. CONCLUSION: The defect in the adipose tissue secretory function during obesity may result in different metabolic disorders including IR. The C3 role during obesity-associated inflammation in IR is emerging. More longitudinal studies are warranted to evaluate the role of C3 among other pro-inflammatory biomarkers for IR.
Authors: Ying Xin; Elisabeth Hertle; Carla J H van der Kallen; Casper G Schalkwijk; Coen D A Stehouwer; Marleen M J van Greevenbroek Journal: Endocrine Date: 2018-08-21 Impact factor: 3.633