Shoujiang You1, Chongke Zhong2, Danni Zheng3, Jiaping Xu1, Xia Zhang1, Huihui Liu1, Yanlin Zhang1, Jijun Shi1, Zhichao Huang1, Yongjun Cao4, Chun-Feng Liu5. 1. Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China. 2. Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, China. 3. The George Institute for Global Health, Royal Prince Alfred Hospital, Sydney, NSW, Australia. 4. Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Institute of Neuroscience, Soochow University, Suzhou 215123, China. Electronic address: yongjuncao@126.com. 5. Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Institute of Neuroscience, Soochow University, Suzhou 215123, China.
Abstract
BACKGROUND: Monocyte and monocyte to high-density lipoprotein ratio (MHR) recently emerged as markers of inflammation and have been reported to be novel prognostic indicators of cardiovascular diseases. We investigated the association of monocyte and MHR with hospital discharge and 3-month outcome after acute intracerebral hemorrhage (ICH). METHODS: A total of 316 patients with acute ICH were enrolled from November 2011 to March 2014. Demographic characteristics, lifestyle risk factors, medical history, admission laboratory parameters, and monocyte level were recorded. Clinical outcome was disability or death (defined as having a modified Rankin Scale score≥2) upon discharge or at 3months. RESULTS: 202 patients (63.9%) experienced disability or death at hospital discharge, and 176 patients (55.7%) at 3months post-ICH. Admission monocyte level was associated with clinical outcome at 3months (adjusted OR, 4.17; 95% CI, 1.45-12.00; P-trend=0.028) when highest and lowest quartiles were compared. However, no significant association was found between monocyte and discharge outcome (P-trend=0.102). Compared to the lowest category of MHR, the highest category was associated with a 3.87-fold increase in the odds of disability or death at discharge (95% CI, 1.17-12.76; P-trend=0.045) and 3.08-fold increased odds of disability or death at 3-month (95% CI, 1.05-9.08; P-trend=0.024). CONCLUSIONS: In patients with acute ICH, higher MHR was associated with increased risk of disability or death at discharge and at 3months post-ICH, however higher monocyte was only associated with increased risk of 3-month disability or death.
BACKGROUND: Monocyte and monocyte to high-density lipoprotein ratio (MHR) recently emerged as markers of inflammation and have been reported to be novel prognostic indicators of cardiovascular diseases. We investigated the association of monocyte and MHR with hospital discharge and 3-month outcome after acute intracerebral hemorrhage (ICH). METHODS: A total of 316 patients with acute ICH were enrolled from November 2011 to March 2014. Demographic characteristics, lifestyle risk factors, medical history, admission laboratory parameters, and monocyte level were recorded. Clinical outcome was disability or death (defined as having a modified Rankin Scale score≥2) upon discharge or at 3months. RESULTS: 202 patients (63.9%) experienced disability or death at hospital discharge, and 176 patients (55.7%) at 3months post-ICH. Admission monocyte level was associated with clinical outcome at 3months (adjusted OR, 4.17; 95% CI, 1.45-12.00; P-trend=0.028) when highest and lowest quartiles were compared. However, no significant association was found between monocyte and discharge outcome (P-trend=0.102). Compared to the lowest category of MHR, the highest category was associated with a 3.87-fold increase in the odds of disability or death at discharge (95% CI, 1.17-12.76; P-trend=0.045) and 3.08-fold increased odds of disability or death at 3-month (95% CI, 1.05-9.08; P-trend=0.024). CONCLUSIONS: In patients with acute ICH, higher MHR was associated with increased risk of disability or death at discharge and at 3months post-ICH, however higher monocyte was only associated with increased risk of 3-month disability or death.
Authors: Anan Shtaya; Leslie R Bridges; Rebecca Williams; Sarah Trippier; Liqun Zhang; Anthony C Pereira; James A R Nicoll; Delphine Boche; Atticus H Hainsworth Journal: Stroke Date: 2021-07-20 Impact factor: 7.914