Literature DB >> 28013411

Genomic effects of glucocorticoids.

Ivana Grbesa1, Ofir Hakim2.   

Abstract

Glucocorticoids and their receptor (GR) have been an important area of research because of their pleiotropic physiological functions and extensive use in the clinic. In addition, the association between GR and glucocorticoids, which is highly specific, leads to rapid nuclear translocation where GR associates with chromatin to regulate gene transcription. This simplified model system has been instrumental for studying the complexity of transcription regulation processes occurring at chromatin. In this review we discuss our current understanding of GR action that has been enhanced by recent developments in genome wide measurements of chromatin accessibility, histone marks, chromatin remodeling and 3D chromatin structure in various cell types responding to glucocorticoids.

Keywords:  ChIP-seq; Chromatin; Chromatin accessibility; Enhancers; Glucocorticoid receptor; Glucocorticoids; Long-range interactions; Transcription; Transcription factor

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Substances：

Year:  2016        PMID： 28013411     DOI： 10.1007/s00709-016-1063-y

Source DB:  PubMed          Journal:  Protoplasma        ISSN： 0033-183X            Impact factor:   3.356


  96 in total

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Journal:  Nat Genet       Date:  2006-10-01       Impact factor: 38.330

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5.  Response Element Composition Governs Correlations between Binding Site Affinity and Transcription in Glucocorticoid Receptor Feed-forward Loops.

Authors:  Sarah K Sasse; Zheng Zuo; Vineela Kadiyala; Liyang Zhang; Miles A Pufall; Mukesh K Jain; Tzu L Phang; Gary D Stormo; Anthony N Gerber
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6.  Interaction of the glucocorticoid receptor with the chromatin landscape.

Authors:  Sam John; Peter J Sabo; Thomas A Johnson; Myong-Hee Sung; Simon C Biddie; Stafford L Lightman; Ty C Voss; Sean R Davis; Paul S Meltzer; John A Stamatoyannopoulos; Gordon L Hager
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7.  Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo.

Authors:  Hee-Woong Lim; N Henriette Uhlenhaut; Alexander Rauch; Juliane Weiner; Sabine Hübner; Norbert Hübner; Kyoung-Jae Won; Mitchell A Lazar; Jan Tuckermann; David J Steger
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9.  A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells.

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Authors:  Yurii Chinenov; Maddalena Coppo; Rebecca Gupte; Maria A Sacta; Inez Rogatsky
Journal:  BMC Genomics       Date:  2014-08-06       Impact factor: 3.969
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  9 in total

1.  Editorial.

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5.  Genome-wide binding potential and regulatory activity of the glucocorticoid receptor's monomeric and dimeric forms.

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8.  Glucocorticoid signaling induces transcriptional memory and universally reversible chromatin changes.

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Review 9.  A Comprehensive Overview on Stress Neurobiology: Basic Concepts and Clinical Implications.

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  9 in total

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