Literature DB >> 2801330

Inhibition of neutrophil adherence to endothelial cells by 3-deazaadenosine.

C H Jurgensen1, G Wolberg, T P Zimmerman.   

Abstract

Treatment of cultured human umbilical vein endothelial cells (HUVE) with tumor necrosis factor alpha (TNF-alpha) increases their capacity to adhere human neutrophils. We have found that 3-deazaadenosine (c3Ado), when added in conjunction with TNF-alpha, inhibited this increase in neutrophil adherence. This activity of c3Ado was potentiated by the addition of L-homocysteine thiolactone (Hcy). The ability of c3Ado to inhibit neutrophil adherence to HUVE may contribute to the anti-inflammatory activity of this nucleoside analogue.

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Year:  1989        PMID： 2801330     DOI： 10.1007/bf01972833

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  6 in total

1.  3-Deazaadenosine-induced disorganization of macrophage microfilaments.

Authors:  C R Stopford; G Wolberg; K L Prus; R Reynolds-Vaughn; T P Zimmerman
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

Review 2.  Pharmacological and biochemical aspects of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase.

Authors:  P M Ueland
Journal:  Pharmacol Rev       Date:  1982-09       Impact factor: 25.468

3.  A rapid one-step procedure for purification of mononuclear and polymorphonuclear leukocytes from human blood using a modification of the Hypaque-Ficoll technique.

Authors:  A Ferrante; Y H Thong
Journal:  J Immunol Methods       Date:  1978       Impact factor: 2.303

4.  3-Deazaadenosine. S-adenosylhomocysteine hydrolase-independent mechanism of action in mouse lymphocytes.

Authors:  T P Zimmerman; M Iannone; G Wolberg
Journal:  J Biol Chem       Date:  1984-01-25       Impact factor: 5.157

5.  Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor.

Authors:  J R Gamble; J M Harlan; S J Klebanoff; M A Vadas
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

6.  Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines.

Authors:  M P Bevilacqua; J S Pober; M E Wheeler; R S Cotran; M A Gimbrone
Journal:  J Clin Invest       Date:  1985-11       Impact factor: 14.808
  6 in total
  1 in total

1.  Role of glycine N-methyltransferase in the regulation of T-cell responses in experimental autoimmune encephalomyelitis.

Authors:  Chung-Hsien Li; Ming-Hong Lin; Shih-Han Chu; Pang-Hsien Tu; Cheng-Chieh Fang; Chia-Hung Yen; Peir-In Liang; Jason C Huang; Yu-Chia Su; Huey-Kang Sytwu; Yi-Ming Arthur Chen
Journal:  Mol Med       Date:  2015-03-24       Impact factor: 6.354
  1 in total

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