Sarah Vigerland1, Eva Serlachius2, Ulrika Thulin3, Gerhard Andersson4, Jan-Olov Larsson5, Brjánn Ljótsson6. 1. Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, 171 77 Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Sweden. Electronic address: sarah.vigerland@ki.se. 2. Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, 171 77 Stockholm, Sweden; Stockholm Health Care Services, Stockholm County Council, Sweden. Electronic address: eva.serlachius@ki.se. 3. Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address: ulrika.thulin@ki.se. 4. Department of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, 171 77 Stockholm, Sweden; Department of Behavioral Sciences and Learning, Linköping University, 581 83 Linköping, Sweden. Electronic address: gerhard.andersson@liu.se. 5. Department of Women's and Children's Health, Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address: jan-olov.larsson@ki.se. 6. Department of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, 171 77 Stockholm, Sweden. Electronic address: brjann.ljotsson@ki.se.
Abstract
OBJECTIVE: This study investigated the long-term outcomes of internet-delivered cognitive behavior therapy (ICBT) for children with anxiety disorders, and potential pre-treatment predictors of treatment outcome. METHOD: The sample included eighty-four children (8-12 years old) with anxiety disorders, from both a treatment group and a waitlist control (after participants had crossed over to treatment) of a previous randomized controlled study. Participants were assessed at post-treatment and three- and twelve-months after treatment using a semi-structured interview and parent ratings. Pre-treatment data were used to investigate predictors of treatment outcome at three-month follow-up. RESULTS: Intention-to-treat analysis showed that treatment gains were maintained at twelve-month follow-up, including clinician rated severity of the principal anxiety disorder, parent rated anxiety symptoms and global functioning, with mainly large effect sizes (Cohen's d = 0.63-2.35). Completer analyses showed that suspected autism spectrum disorder was associated with less change in symptom severity. No other pre-treatment measures significantly predicted treatment outcome. CONCLUSION: This study suggests that internet-delivered CBT can have long-term beneficial effects for children with anxiety disorders. Predictors of treatment outcome need to be evaluated further. TRIAL REGISTRATION: Clinicaltrials.gov; NCT01533402.
RCT Entities:
OBJECTIVE: This study investigated the long-term outcomes of internet-delivered cognitive behavior therapy (ICBT) for children with anxiety disorders, and potential pre-treatment predictors of treatment outcome. METHOD: The sample included eighty-four children (8-12 years old) with anxiety disorders, from both a treatment group and a waitlist control (after participants had crossed over to treatment) of a previous randomized controlled study. Participants were assessed at post-treatment and three- and twelve-months after treatment using a semi-structured interview and parent ratings. Pre-treatment data were used to investigate predictors of treatment outcome at three-month follow-up. RESULTS: Intention-to-treat analysis showed that treatment gains were maintained at twelve-month follow-up, including clinician rated severity of the principal anxiety disorder, parent rated anxiety symptoms and global functioning, with mainly large effect sizes (Cohen's d = 0.63-2.35). Completer analyses showed that suspected autism spectrum disorder was associated with less change in symptom severity. No other pre-treatment measures significantly predicted treatment outcome. CONCLUSION: This study suggests that internet-delivered CBT can have long-term beneficial effects for children with anxiety disorders. Predictors of treatment outcome need to be evaluated further. TRIAL REGISTRATION: Clinicaltrials.gov; NCT01533402.
Authors: Ashley D Radomski; Lori Wozney; Patrick McGrath; Anna Huguet; Lisa Hartling; Michele P Dyson; Kathryn Bennett; Amanda S Newton Journal: J Med Internet Res Date: 2019-02-05 Impact factor: 5.428
Authors: Ashley D Radomski; Lori Wozney; Patrick McGrath; Anna Huguet; Lisa Hartling; Michele P Dyson; Kathryn J Bennett; Amanda S Newton Journal: JMIR Ment Health Date: 2019-10-23
Authors: Sumaiya Islam; Cordelia Elaiho; Guedy Arniella; Sheydgi Rivera; Nita Vangeepuram Journal: Int J Environ Res Public Health Date: 2022-09-27 Impact factor: 4.614