Literature DB >> 28011223

Identification of a diverse synthetic abietane diterpenoid library for anticancer activity.

Hongtao Xu1, Lili Liu2, Xiaoting Fan3, Guanjun Zhang4, Yuanchao Li5, Biao Jiang6.   

Abstract

A diverse natural-product-like synthetic abietane diterpenoid library contains about 56 compounds were obtained, and evaluated for their potential in vitro cytotoxic or antitumor activity against A549, PC-3 and SKOV-3 tumor cell lines by SRB assay. Treatment of A549 cells with the most potent compound ketone 19 showed induction of apoptosis, as revealed by JC-1 mitochondrial membrane potential staining, TUNNEL assay, western blotting analysis and flow cytometry assay.
Copyright © 2016 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Abietic acid; Anticancer; Diverse; Natural-product-like; Triptophenolide

Mesh：

Substances：

Year:  2016        PMID： 28011223     DOI： 10.1016/j.bmcl.2016.12.032

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Synthesis and In Vitro Anticancer Activity of Novel Dehydroabietic Acid-Based Acylhydrazones.

Authors:  Fang-Yao Li; Xiu Wang; Wen-Gui Duan; Gui-Shan Lin
Journal:  Molecules       Date:  2017-06-29       Impact factor: 4.411

2.  Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis.

Authors:  Evijola Llabani; Robert W Hicklin; Hyang Yeon Lee; Stephen E Motika; Lisa A Crawford; Eranthie Weerapana; Paul J Hergenrother
Journal:  Nat Chem       Date:  2019-05-13       Impact factor: 24.427

3.  Development and Mechanistic Insight into the Enhanced Cytotoxic Potential of Parvifloron D Albumin Nanoparticles in EGFR-Overexpressing Pancreatic Cancer Cells.

Authors:  Ana Santos-Rebelo; Pradeep Kumar; Viness Pillay; Yahya E Choonara; Carla Eleutério; Mariana Figueira; Ana S Viana; Lia Ascensão; Jesús Molpeceres; Patrícia Rijo; Isabel Correia; Joana Amaral; Susana Solá; Cecília M P Rodrigues; Maria Manuela Gaspar; Catarina Pinto Reis
Journal:  Cancers (Basel)       Date:  2019-11-05       Impact factor: 6.639

4.  Synthesis and biological evaluation of dehydroabietic acid-pyrimidine hybrids as antitumor agents.

Authors:  Lin Huang; Rong Huang; Fuhua Pang; Anke Li; Guobao Huang; Xiaoqun Zhou; Qian Li; Fangyao Li; Xianli Ma
Journal:  RSC Adv       Date:  2020-05-11       Impact factor: 4.036

5.  Effect of Modified Levopimaric Acid Diene Adducts on Mitochondrial and Liposome Membranes.

Authors:  Mikhail V Dubinin; Vyacheslav A Sharapov; Alena A Semenova; Lyudmila V Parfenova; Anna I Ilzorkina; Ekaterina I Khoroshavina; Natalia V Belosludtseva; Sergey V Gudkov; Konstantin N Belosludtsev
Journal:  Membranes (Basel)       Date:  2022-09-08

6.  Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis.

Authors:  Thobias M Kalenga; Jackson T Mollel; Joanna Said; Andreas Orthaber; Jas S Ward; Yoseph Atilaw; Daniel Umereweneza; Monica M Ndoile; Joan J E Munissi; Kari Rissanen; Edward Trybala; Tomas Bergström; Stephen S Nyandoro; Mate Erdelyi
Journal:  J Nat Prod       Date:  2022-09-08       Impact factor: 4.803

Review 7.  Recent Advances on Biological Activities and Structural Modifications of Dehydroabietic Acid.

Authors:  Meng Hao; Jianwei Xu; Houpeng Wen; Jiawei Du; Shaoyong Zhang; Min Lv; Hui Xu
Journal:  Toxins (Basel)       Date:  2022-09-12       Impact factor: 5.075

Review 8.  A review of the total syntheses of triptolide.

Authors:  Xiang Zhang; Zaozao Xiao; Hongtao Xu
Journal:  Beilstein J Org Chem       Date:  2019-08-22       Impact factor: 2.883
  8 in total

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