J A Wallis1, K E Webster2, P Levinger3, P J Singh4, C Fong5, N F Taylor6. 1. School of Allied Health, La Trobe University, Australia; Department of Physiotherapy, Eastern Health, Australia. Electronic address: Jason.wallis@easternhealth.org.au. 2. School of Allied Health, La Trobe University, Australia. 3. Institute of Sport, Exercise & Active Living (ISEAL), Victoria University, Australia. 4. Department of Orthopaedics, Eastern Health, Monash and Deakin University, Australia. 5. Department of Rheumatology, Eastern Health, Monash University, Australia. 6. School of Allied Health, La Trobe University, Australia; Department of Physiotherapy, Eastern Health, Australia.
Abstract
OBJECTIVE: The primary aim was to evaluate the effect of a dosed walking program on knee pain for patients with severe knee osteoarthritis (OA). Secondary aims evaluated the effects on cardiovascular health, function and quality of life. DESIGN:Participants with severe knee OA and increased cardiovascular risk were randomly assigned to a 12-week walking program of 70 min/week of at least moderate intensity, or to usual care. The primary outcome was knee pain (0-10). Secondary outcomes were of cardiovascular risk including physical activity, blood pressure, blood lipid and glucose levels, body mass index and waist circumference; WOMAC Index scores; physical function; and quality of life. RESULTS:Forty-six participants (23 each group) were recruited. Sixteen participants (70%) adhered to the walking program. Intention to treat analysis showed no between-group difference in knee pain. The walking group had increased odds of achieving a healthy systolic blood pressure (OR = 5.7, 95% CI 1.2-26.9), and a faster walking speed (Mean Difference (MD) = 0.12 m/s, 95% CI 0.02-0.23). Per protocol analysis based on participant adherence showed the walking group had more daily steps (MD = 1345 steps, 95% CI 365-2325); more time walking (MD = 18 min/day, 95% CI 5-31); reduced waist circumference (MD = -5.3 cm, 95% CI -10.5 to -0.03); and increased knee stiffness (MD = 0.9 units, 95% CI 0.07-1.8). CONCLUSIONS:Patients with severe knee OA prescribed a 12-week walking program of 70 min/week may have had cardiovascular benefits without decreasing knee pain. Australian New Zealand Clinical Trials Registry ACTRN12615000015549.
RCT Entities:
OBJECTIVE: The primary aim was to evaluate the effect of a dosed walking program on knee pain for patients with severe knee osteoarthritis (OA). Secondary aims evaluated the effects on cardiovascular health, function and quality of life. DESIGN:Participants with severe knee OA and increased cardiovascular risk were randomly assigned to a 12-week walking program of 70 min/week of at least moderate intensity, or to usual care. The primary outcome was knee pain (0-10). Secondary outcomes were of cardiovascular risk including physical activity, blood pressure, blood lipid and glucose levels, body mass index and waist circumference; WOMAC Index scores; physical function; and quality of life. RESULTS: Forty-six participants (23 each group) were recruited. Sixteen participants (70%) adhered to the walking program. Intention to treat analysis showed no between-group difference in knee pain. The walking group had increased odds of achieving a healthy systolic blood pressure (OR = 5.7, 95% CI 1.2-26.9), and a faster walking speed (Mean Difference (MD) = 0.12 m/s, 95% CI 0.02-0.23). Per protocol analysis based on participant adherence showed the walking group had more daily steps (MD = 1345 steps, 95% CI 365-2325); more time walking (MD = 18 min/day, 95% CI 5-31); reduced waist circumference (MD = -5.3 cm, 95% CI -10.5 to -0.03); and increased knee stiffness (MD = 0.9 units, 95% CI 0.07-1.8). CONCLUSIONS:Patients with severe knee OA prescribed a 12-week walking program of 70 min/week may have had cardiovascular benefits without decreasing knee pain. Australian New Zealand Clinical Trials Registry ACTRN12615000015549.
Authors: Ling-Ling Lee; Caroline A Mulvaney; Yoko Kin Yoke Wong; Edwin Sy Chan; Michael C Watson; Hui-Hsin Lin Journal: Cochrane Database Syst Rev Date: 2021-02-24
Authors: Bryan Yijia Tan; Tivona Thach; Yasmin Lynda Munro; Soren Thorgaard Skou; Julian Thumboo; Josip Car; Lorainne Tudor Car Journal: Int J Environ Res Public Health Date: 2021-12-03 Impact factor: 3.390
Authors: George S Metsios; Nina Brodin; Thea P M Vliet Vlieland; Cornelia H M Van den Ende; Antonios Stavropoulos-Kalinoglou; Ioannis Fatouros; Martin van der Esch; Sally A M Fenton; Katerina Tzika; Rikke Helene Moe; Jet J C S Veldhuijzen van Zanten; Yiannis Koutedakis; Thijs Willem Swinnen; Aristidis S Veskoukis; Carina Boström; Norelee Kennedy; Elena Nikiphorou; George E Fragoulis; Karin Niedermann; George D Kitas Journal: Mediterr J Rheumatol Date: 2021-12-27