Derrick P Smit1, Tonya M Esterhuizen2, David Meyer1. 1. a Division of Ophthalmology, Faculty of Medicine and Health Sciences , Stellenbosch University , Cape Town , South Africa. 2. b Biostatistics Unit, Centre for Evidence Based Health Care, Faculty of Medicine and Health Sciences , Stellenbosch University , Cape Town , South Africa.
Abstract
PURPOSE: To report the prevalence of intraocular tuberculosis in South Africa using a revised classification system. METHODS: A prospective study to determine the underlying etiology in patients presenting with uveitis to a tertiary Eye Clinic. RESULTS: A total of 35 out of 106 patients (33.0%) were diagnosed with intraocular tuberculosis, of which 11 (31.4%) had HIV infection; 23 patients (65.7%) had possible intraocular tuberculosis and 12 (34.3%) had probable intraocular tuberculosis. Patients with probable intraocular tuberculosis were younger than those with possible intraocular tuberculosis (p = 0.003). More males (66.7%) had probable intraocular tuberculosis and more females (73.9%) had possible intraocular tuberculosis (p = 0.031). More HIV-positive patients had probable intraocular tuberculosis and more HIV-negative patients had possible intraocular tuberculosis (p = 0.002). CONCLUSIONS: South Africa has a high prevalence of intraocular tuberculosis. Younger, male, HIV-positive patients are more likely to have probable intraocular tuberculosis, while older, female, HIV-negative patients are more likely to have possible intraocular tuberculosis.
PURPOSE: To report the prevalence of intraocular tuberculosis in South Africa using a revised classification system. METHODS: A prospective study to determine the underlying etiology in patients presenting with uveitis to a tertiary Eye Clinic. RESULTS: A total of 35 out of 106 patients (33.0%) were diagnosed with intraocular tuberculosis, of which 11 (31.4%) had HIV infection; 23 patients (65.7%) had possible intraocular tuberculosis and 12 (34.3%) had probable intraocular tuberculosis. Patients with probable intraocular tuberculosis were younger than those with possible intraocular tuberculosis (p = 0.003). More males (66.7%) had probable intraocular tuberculosis and more females (73.9%) had possible intraocular tuberculosis (p = 0.031). More HIV-positivepatients had probable intraocular tuberculosis and more HIV-negative patients had possible intraocular tuberculosis (p = 0.002). CONCLUSIONS: South Africa has a high prevalence of intraocular tuberculosis. Younger, male, HIV-positivepatients are more likely to have probable intraocular tuberculosis, while older, female, HIV-negative patients are more likely to have possible intraocular tuberculosis.
Entities:
Keywords:
Classification; HIV; South Africa; intraocular tuberculosis; prevalence
Authors: Luis Anibarro; Eliana Cortés; Ana Chouza; Alberto Parafita-Fernández; Juan Carlos García; Alberto Pena; Carlos Fernández-Cid; África González-Fernández Journal: Infection Date: 2018-06-04 Impact factor: 3.553
Authors: Rivka R Lilian; Jean Railton; Erik Schaftenaar; Moyahabo Mabitsi; Cornelis J Grobbelaar; N Sellina Khosa; Babra H Maluleke; Helen E Struthers; James A McIntyre; Remco P H Peters Journal: PLoS One Date: 2018-05-14 Impact factor: 3.240