Shakeel Ahmed Ansari1, Rukhsana Satar, Asma Perveen, Ghulam Md Ashraf. 1. aCenter of Excellence in Genomic Medicine Research, King Abdulaziz University bDepartment of Biochemistry, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia cDepartment of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India dKing Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Abstract
PURPOSE OF REVIEW: Nanotechnology typically deals with the measuring and modeling of matter at nanometer scale by incorporating the fields of engineering and technology. The most prominent feature of these engineered materials involves their manipulation/modification for imparting new functional properties. The current review covers the most recent findings of Alzheimer's disease (AD) therapeutics based on nanoscience and technology. RECENT FINDINGS: Current studies involve the application of nanotechnology in developing novel diagnostic and therapeutic tools for neurological disorders. Nanotechnology-based approaches can be exploited for limiting/reversing these diseases for promoting functional regeneration of damaged neurons. These strategies offer neuroprotection by facilitating the delivery of drugs and small molecules more effectively across the blood-brain barrier. SUMMARY: Nanotechnology based approaches show promise in improving AD therapeutics. Further replication work on synthesis and surface modification of nanoparticles, longer-term clinical trials, and attempts to increase their impact in treating AD are required.
PURPOSE OF REVIEW: Nanotechnology typically deals with the measuring and modeling of matter at nanometer scale by incorporating the fields of engineering and technology. The most prominent feature of these engineered materials involves their manipulation/modification for imparting new functional properties. The current review covers the most recent findings of Alzheimer's disease (AD) therapeutics based on nanoscience and technology. RECENT FINDINGS: Current studies involve the application of nanotechnology in developing novel diagnostic and therapeutic tools for neurological disorders. Nanotechnology-based approaches can be exploited for limiting/reversing these diseases for promoting functional regeneration of damaged neurons. These strategies offer neuroprotection by facilitating the delivery of drugs and small molecules more effectively across the blood-brain barrier. SUMMARY: Nanotechnology based approaches show promise in improving AD therapeutics. Further replication work on synthesis and surface modification of nanoparticles, longer-term clinical trials, and attempts to increase their impact in treating AD are required.
Authors: Anna Brzecka; Jerzy Leszek; Ghulam Md Ashraf; Maria Ejma; Marco F Ávila-Rodriguez; Nagendra S Yarla; Vadim V Tarasov; Vladimir N Chubarev; Anna N Samsonova; George E Barreto; Gjumrakch Aliev Journal: Front Neurosci Date: 2018-05-31 Impact factor: 4.677
Authors: Amira G Zaki; El-Sayed R El-Sayed; M Abd Elkodous; Gharieb S El-Sayyad Journal: Appl Microbiol Biotechnol Date: 2020-04-13 Impact factor: 5.560