| Literature DB >> 28009461 |
Flavia Fontana1, Mohammad-Ali Shahbazi1, Dongfei Liu1,2, Hongbo Zhang1,2, Ermei Mäkilä3, Jarno Salonen3, Jouni T Hirvonen1, Hélder A Santos1.
Abstract
Immunoadjuvant porous silicon (PSi)-based nanovaccines are prepared by nanoprecipitation in a glass capillary microfluidics device. Vesicles, derived from cancer cell membranes encapsulating thermally oxidized PSi nanoparticles or PSi-polymer nanosystems binding a model antigen, are biocompatible over a wide range of concentrations, and show immunostimulant properties in human cells, promoting the expression of co-stimulatory signals and the secretion of pro-inflammatory cytokines.Entities:
Keywords: acetalated dextran; cancer cell membranes; cancer immunotherapy; nanovaccines; porous silicon
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Year: 2016 PMID: 28009461 DOI: 10.1002/adma.201603239
Source DB: PubMed Journal: Adv Mater ISSN: 0935-9648 Impact factor: 30.849