| Literature DB >> 28009098 |
Li Lin1, Junjie Yao1,2, Ruiying Zhang1, Chun-Cheng Chen3, Chih-Hsien Huang4, Yang Li1, Lidai Wang1,5, William Chapman3, Jun Zou4, Lihong V Wang1.
Abstract
We applied high-speed photoacoustic microscopy (PAM) for both cortical microenvironment studies and dynamic brain studies, with micrometer-level optical resolution and a millisecond-level cross-sectional imaging speed over a millimeter-level field of view. We monitored blood flow redistribution in mini-stroke mouse models and cerebral autoregulation induced by a vasoactive agent. Our results collectively suggest that high-speed PAM is a promising tool for understanding dynamic neurophysiological phenomena, complementing conventional imaging modalities.Entities:
Keywords: MEMS scanning mirror; blood flow redistribution; cerebral autoregulation; cortical hemodynamics; microhemorrhage; photoacoustic microscopy
Mesh:
Year: 2016 PMID: 28009098 PMCID: PMC5576888 DOI: 10.1002/jbio.201600236
Source DB: PubMed Journal: J Biophotonics ISSN: 1864-063X Impact factor: 3.207