Matias C Vieira1, Lucilla Poston1, Elaine Fyfe2, Alexandra Gillett1, Louise C Kenny3, Claire T Roberts4, Philip N Baker5, Jenny E Myers6, James J Walker7, Lesley M McCowan2, Robyn A North1, Dharmintra Pasupathy1. 1. Division of Women's Health, Women's Health Academic Centre, King's College London and King's Health Partners, London, UK. 2. Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. 3. The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Department of Obstetrics and Gynaecology, University College Cork, Cork University Maternity Hospital, Wilton, Cork, Ireland. 4. Discipline of Obstetrics and Gynaecology, Robinson Research Institute, University of Adelaide, Adelaide, South Australia. 5. College of Medicine, Biological Sciences & Psychology, University of Leicester, UK. 6. Division of Developmental Biology, School of Medical Sciences, The Faculty of Biology Medicine and Health, Manchester Academic Heath Science Centre, University of Manchester, UK. 7. Department of Obstetrics and Gynaecology, Leeds Institute of Biomedical & Clinical Sciences, University of Leeds, UK.
Abstract
OBJECTIVE: To compare early pregnancy clinical and biomarker risk factors for later development of preeclampsia between women with obesity (body mass index, BMI ≥30 kg/m2 ) and those with a normal BMI (20-25 kg/m2 ). METHODS: In 3,940 eligible nulliparous women from the Screening for Pregnancy Endpoints (SCOPE) study, a total of 53 biomarkers of glucose and lipid metabolism, placental function, and known markers of preeclampsia were measured at 14 to 16 weeks' gestation. Logistic regression was performed to identify clinical and biomarker risk factors for preeclampsia in women with and without obesity. RESULTS: Among 834 women with obesity and 3,106 with a normal BMI, 77 (9.2%) and 105 (3.4%) developed preeclampsia, respectively. In women with obesity, risk factors included a family history of thrombotic disease, low plasma placental growth factor, and higher uterine artery resistance index at 20 weeks. In women with a normal BMI, a family history of preeclampsia or gestational hypertension, mean arterial blood pressure, plasma endoglin and cystatin C, and uterine artery resistance index were associated with preeclampsia, while high fruit intake was protective. CONCLUSIONS: Women with obesity and a normal BMI have different early pregnancy clinical and biomarker risk factors for preeclampsia.
OBJECTIVE: To compare early pregnancy clinical and biomarker risk factors for later development of preeclampsia between women with obesity (body mass index, BMI ≥30 kg/m2 ) and those with a normal BMI (20-25 kg/m2 ). METHODS: In 3,940 eligible nulliparous women from the Screening for Pregnancy Endpoints (SCOPE) study, a total of 53 biomarkers of glucose and lipid metabolism, placental function, and known markers of preeclampsia were measured at 14 to 16 weeks' gestation. Logistic regression was performed to identify clinical and biomarker risk factors for preeclampsia in women with and without obesity. RESULTS: Among 834 women with obesity and 3,106 with a normal BMI, 77 (9.2%) and 105 (3.4%) developed preeclampsia, respectively. In women with obesity, risk factors included a family history of thrombotic disease, low plasma placental growth factor, and higher uterine artery resistance index at 20 weeks. In women with a normal BMI, a family history of preeclampsia or gestational hypertension, mean arterial blood pressure, plasma endoglin and cystatin C, and uterine artery resistance index were associated with preeclampsia, while high fruit intake was protective. CONCLUSIONS: Women with obesity and a normal BMI have different early pregnancy clinical and biomarker risk factors for preeclampsia.
Authors: Matias C Vieira; Sara L White; Nashita Patel; Paul T Seed; Annette L Briley; Jane Sandall; Paul Welsh; Naveed Sattar; Scott M Nelson; Debbie A Lawlor; Lucilla Poston; Dharmintra Pasupathy Journal: BMC Med Date: 2017-11-03 Impact factor: 8.775
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Authors: Erika Chavira-Suárez; Luis Antonio Reyes-Castro; Itzel Ivonn López-Tenorio; Lilia Vargas-Hernández; Guadalupe L Rodríguez-González; Roberto Chavira; Paola Zárate-Segura; Aaron Domínguez-López; Felipe Vadillo-Ortega; Elena Zambrano Journal: Front Cell Dev Biol Date: 2022-08-16