A Li1, S Robiou-du-Pont1, S S Anand1,2, K M Morrison2,3, S D McDonald1,4, S A Atkinson3, K K Teo1,2, D Meyre1,5. 1. Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada. 2. Department of Medicine, McMaster University, Hamilton, Ontario, Canada. 3. Department of Pediatrics, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada. 4. Department of Obstetrics and Gynecology, McMaster University, Hamilton, Ontario, Canada. 5. Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Abstract
BACKGROUND: The genetic influence on child obesity has not been fully elucidated. OBJECTIVE: This study investigated the parental and child contributions of 83 adult body mass index (BMI)-associated single-nucleotide polymorphisms (SNPs) to obesity-related traits in children from birth to 5 years old. METHODS: A total of 1402 individuals were genotyped for 83 SNPs. An unweighted genetic risk score (GRS) was generated by the sum of BMI-increasing alleles. Repeated weight and length/height were measured at birth, 1, 2, 3 and 5 years of age, and age-specific and sex-specific weight and BMI Z-scores were computed. RESULTS: The GRS was significantly associated with birthweight Z-score (P = 0.03). It was also associated with weight/BMI Z-score gain between birth and 5 years old (P = 0.02 and 6.77 × 10-3 , respectively). In longitudinal analyses, the GRS was associated with weight and BMI Z-score from birth to 5 years (P = 5.91 × 10-3 and 5.08 × 10-3 , respectively). The maternal effects of rs3736485 in DMXL2 on weight and BMI variation from birth to 5 years were significantly greater compared with the paternal effects by Z test (P = 1.53 × 10-6 and 3.75 × 10-5 , respectively). CONCLUSIONS: SNPs contributing to adult BMI exert their effect at birth and in early childhood. Parent-of-origin effects may occur in a limited subset of obesity predisposing SNPs.
BACKGROUND: The genetic influence on childobesity has not been fully elucidated. OBJECTIVE: This study investigated the parental and child contributions of 83 adult body mass index (BMI)-associated single-nucleotide polymorphisms (SNPs) to obesity-related traits in children from birth to 5 years old. METHODS: A total of 1402 individuals were genotyped for 83 SNPs. An unweighted genetic risk score (GRS) was generated by the sum of BMI-increasing alleles. Repeated weight and length/height were measured at birth, 1, 2, 3 and 5 years of age, and age-specific and sex-specific weight and BMI Z-scores were computed. RESULTS: The GRS was significantly associated with birthweight Z-score (P = 0.03). It was also associated with weight/BMI Z-score gain between birth and 5 years old (P = 0.02 and 6.77 × 10-3 , respectively). In longitudinal analyses, the GRS was associated with weight and BMI Z-score from birth to 5 years (P = 5.91 × 10-3 and 5.08 × 10-3 , respectively). The maternal effects of rs3736485 in DMXL2 on weight and BMI variation from birth to 5 years were significantly greater compared with the paternal effects by Z test (P = 1.53 × 10-6 and 3.75 × 10-5 , respectively). CONCLUSIONS: SNPs contributing to adult BMI exert their effect at birth and in early childhood. Parent-of-origin effects may occur in a limited subset of obesity predisposing SNPs.
Authors: A E Justice; G Chittoor; E Blanco; M Graff; Y Wang; C Albala; J L Santos; B Angel; B Lozoff; V S Voruganti; K E North; S Gahagan Journal: Pediatr Obes Date: 2018-12-04 Impact factor: 4.000
Authors: Einat Granot-Hershkovitz; Peitao Wu; David Karasik; Inga Peter; Gina M Peloso; Daniel Levy; Ramachandran S Vasan; L Adrienne Cupples; Ching-Ti Liu; James B Meigs; David S Siscovick; Josée Dupuis; Yechiel Friedlander; Hagit Hochner Journal: Eur J Hum Genet Date: 2020-01-02 Impact factor: 4.246
Authors: Sébastien Robiou-du-Pont; Sonia S Anand; Katherine M Morrison; Sarah D McDonald; Stephanie A Atkinson; Koon K Teo; David Meyre Journal: PLoS One Date: 2017-10-18 Impact factor: 3.240
Authors: Kuan-Wen Wang; Russell J de Souza; Adam Fleming; Donna L Johnston; Shayna M Zelcer; Shahrad Rod Rassekh; Sarah Burrow; Lehana Thabane; M Constantine Samaan Journal: Sci Rep Date: 2018-01-26 Impact factor: 4.379