Literature DB >> 28008217

Anticancer properties of baicalein: a review.

Ying Gao1, Shane A Snyder2, Jaclyn N Smith2, Yi Charlie Chen2.   

Abstract

The constituents of many traditional Chinese herbal remedies are currently at the forefront of modern cancer research. Baicalein, a bioactive flavone widely used in nutraceuticals and pharmaceuticals, has shown great potential in the treatment and prevention of cancer without causing severe side effects. Baicalein induces cancer cell apoptosis and cause cell cycle arrest. It shows inhibitory effects on angiogenesis, metastasis and inflammation, all of which are necessary for the promotion and progression of cancer. This review presents an overview of the anti-cancer effects and mechanisms of baicalein. In addition, the bioavailability of baicalein and approaches to improve it are summarized. Treatments of baicalein in combination with other anti-cancer agents are also mentioned.

Entities:  

Keywords:  Angiogenesis; Apoptosis; Baicalein; Bioavailability; Metastasis

Year:  2016        PMID： 28008217      PMCID： PMC5166718          DOI： 10.1007/s00044-016-1607-x

Source DB:  PubMed          Journal:  Med Chem Res        ISSN： 1054-2523            Impact factor:   1.965


  81 in total

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Authors:  Wei-Gang Tong; Xian-Zhong Ding; Thomas E Adrian
Journal:  Biochem Biophys Res Commun       Date:  2002-08-30       Impact factor: 3.575

2.  Inhibition of 12-lipoxygenase during baicalein-induced human lung nonsmall carcinoma H460 cell apoptosis.

Authors:  Henry W C Leung; W H Yang; M Y Lai; C J Lin; H Z Lee
Journal:  Food Chem Toxicol       Date:  2006-09-08       Impact factor: 6.023

Review 3.  Pharmacological effects and pharmacokinetics properties of Radix Scutellariae and its bioactive flavones.

Authors:  Chenrui Li; Ge Lin; Zhong Zuo
Journal:  Biopharm Drug Dispos       Date:  2011-09-19       Impact factor: 1.627

Review 4.  Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.

Authors:  Young Jin Moon; Xiaodong Wang; Marilyn E Morris
Journal:  Toxicol In Vitro       Date:  2005-11-11       Impact factor: 3.500

5.  Preparation, characterization and in vivo evaluation of formulation of baicalein with hydroxypropyl-beta-cyclodextrin.

Authors:  Jun Liu; Liyan Qiu; Jianqing Gao; Yi Jin
Journal:  Int J Pharm       Date:  2006-02-03       Impact factor: 5.875

6.  The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells.

Authors:  Qian-mei Zhou; Song Wang; Hui Zhang; Yi-yu Lu; Xiu-feng Wang; Yoshiharu Motoo; Shi-bing Su
Journal:  Acta Pharmacol Sin       Date:  2009-12       Impact factor: 6.150

7.  Scutellaria extract decreases the proportion of side population cells in a myeloma cell line by down-regulating the expression of ABCG2 protein.

Authors:  Mei-Gui Lin; Li-Ping Liu; Chen-Yin Li; Meng Zhang; Yuling Chen; Jian Qin; Yue-Yu Gu; Zhi Li; Xin-Lin Wu; Sui-Lin Mo
Journal:  Asian Pac J Cancer Prev       Date:  2013

8.  Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF-7 human breast cancer cells.

Authors:  Chong-Zhi Wang; Xiao-Li Li; Qian-Fei Wang; Sangeeta R Mehendale; Chun-Su Yuan
Journal:  Phytomedicine       Date:  2010-01       Impact factor: 5.340

Review 9.  ROS stress in cancer cells and therapeutic implications.

Authors:  Helene Pelicano; Dennis Carney; Peng Huang
Journal:  Drug Resist Updat       Date:  2004-04       Impact factor: 18.500

10.  Baicalein mediates inhibition of migration and invasiveness of skin carcinoma through Ezrin in A431 cells.

Authors:  Bin Wu; Ji Li; Damao Huang; Weiwei Wang; Yu Chen; Youxiang Liao; Xiaowei Tang; Hongfu Xie; Faqing Tang
Journal:  BMC Cancer       Date:  2011-12-28       Impact factor: 4.430
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  14 in total

Review 1.  Phytochemicals in thyroid cancer: analysis of the preclinical studies.

Authors:  Stefania Bulotta; Francesca Capriglione; Marilena Celano; Valeria Pecce; Diego Russo; Valentina Maggisano
Journal:  Endocrine       Date:  2021-02-15       Impact factor: 3.633

Review 2.  The Role of Epigenetic Modifications in Human Cancers and the Use of Natural Compounds as Epidrugs: Mechanistic Pathways and Pharmacodynamic Actions.

Authors:  Abdelhakim Bouyahya; Hamza Mechchate; Loubna Oumeslakht; Ikrame Zeouk; Sara Aboulaghras; Abdelaali Balahbib; Gokhan Zengin; Mohammad Amjad Kamal; Monica Gallo; Domenico Montesano; Nasreddine El Omari
Journal:  Biomolecules       Date:  2022-02-25

Review 3.  Baicalein, Baicalin, and Wogonin: Protective Effects against Ischemia-Induced Neurodegeneration in the Brain and Retina.

Authors:  Li Pan; Kin-Sang Cho; Irvin Yi; Chi-Ho To; Dong Feng Chen; Chi-Wai Do
Journal:  Oxid Med Cell Longev       Date:  2021-06-29       Impact factor: 7.310

4.  Characterization of Compounds with Tumor-Cell Proliferation Inhibition Activity from Mushroom (Phellinus baumii) Mycelia Produced by Solid-State Fermentation.

Authors:  Henan Zhang; Qian Shao; Wenhan Wang; Jingsong Zhang; Zhong Zhang; Yanfang Liu; Yan Yang
Journal:  Molecules       Date:  2017-04-27       Impact factor: 4.411

5.  Synthesis of Novel Baicalein Amino Acid Derivatives and Biological Evaluation as Neuroprotective Agents.

Authors:  Xiaohui Jia; Menglu Jia; Yuqin Yang; Di Wang; Fei Zhou; Wenxi Zhang; Xuemei Huang; Wenbo Guo; Desheng Cai; Hongshan Chen; Jinchai Qi; Shuqi Zhou; Haomiao Ren; Bing Xu; Tao Ma; Penglong Wang; Haimin Lei
Journal:  Molecules       Date:  2019-10-09       Impact factor: 4.411

6.  Human Lanosterol 14-Alpha Demethylase (CYP51A1) Is a Putative Target for Natural Flavonoid Luteolin 7,3'-Disulfate.

Authors:  Leonid Kaluzhskiy; Pavel Ershov; Evgeniy Yablokov; Tatsiana Shkel; Irina Grabovec; Yuri Mezentsev; Oksana Gnedenko; Sergey Usanov; Polina Shabunya; Sviatlana Fatykhava; Alexander Popov; Aleksandr Artyukov; Olga Styshova; Andrei Gilep; Natallia Strushkevich; Alexis Ivanov
Journal:  Molecules       Date:  2021-04-13       Impact factor: 4.411

Review 7.  An Update on Pharmacological Relevance and Chemical Synthesis of Natural Products and Derivatives with Anti SARS-CoV-2 Activity.

Authors:  Irshad Ahmad
Journal:  ChemistrySelect       Date:  2021-11-08       Impact factor: 2.109

Review 8.  Roles of Nrf2 in Gastric Cancer: Targeting for Therapeutic Strategies.

Authors:  Tahereh Farkhondeh; Ali Mohammad Pourbagher-Shahri; Mohsen Azimi-Nezhad; Fatemeh Forouzanfar; Aranka Brockmueller; Milad Ashrafizadeh; Marjan Talebi; Mehdi Shakibaei; Saeed Samarghandian
Journal:  Molecules       Date:  2021-05-25       Impact factor: 4.411

Review 9.  Neuroprotective and Cognitive Enhancement Potentials of Baicalin: A Review.

Authors:  Kandhasamy Sowndhararajan; Ponnuvel Deepa; Minju Kim; Se Jin Park; Songmun Kim
Journal:  Brain Sci       Date:  2018-06-11

10.  The interaction between cucurbit[8]uril and baicalein and the effect on baicalein properties.

Authors:  Xiaodong Zhang; Jun Xie; Zhiling Xu; Zhu Tao; Qianjun Zhang
Journal:  Beilstein J Org Chem       Date:  2020-01-10       Impact factor: 2.883
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