Literature DB >> 28008038

Response to Comment on "Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2".

Lianying Jiao1, Xin Liu2.   

Abstract

Zhang et al suggested that in the crystal structure of a polycomb repressive complex 2 from Chaetomium thermophilum (ctPRC2), a flexible linker region, but not the H3K27M cancer mutant peptide, better fits the electron density. Based on our new data, we agree with this alternative interpretation and provide the crystal structure of ctPRC2 bound to a bona fide H3K27M sequence.
Copyright © 2016, American Association for the Advancement of Science.

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Year:  2016        PMID： 28008038      PMCID： PMC5724769          DOI： 10.1126/science.aaj2335

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  4 in total

1.  Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2.

Authors:  Lianying Jiao; Xin Liu
Journal:  Science       Date:  2015-10-15       Impact factor: 47.728

2.  Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.

Authors:  Peter W Lewis; Manuel M Müller; Matthew S Koletsky; Francisco Cordero; Shu Lin; Laura A Banaszynski; Benjamin A Garcia; Tom W Muir; Oren J Becher; C David Allis
Journal:  Science       Date:  2013-03-28       Impact factor: 47.728

3.  Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.

Authors:  Alexei Brooun; Ketan S Gajiwala; Ya-Li Deng; Wei Liu; Ben Bolaños; Patrick Bingham; You-Ai He; Wade Diehl; Nicole Grable; Pei-Pei Kung; Scott Sutton; Karen A Maegley; Xiu Yu; Al E Stewart
Journal:  Nat Commun       Date:  2016-04-28       Impact factor: 14.919

4.  Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.

Authors:  Neil Justin; Ying Zhang; Cataldo Tarricone; Stephen R Martin; Shuyang Chen; Elizabeth Underwood; Valeria De Marco; Lesley F Haire; Philip A Walker; Danny Reinberg; Jon R Wilson; Steven J Gamblin
Journal:  Nat Commun       Date:  2016-04-28       Impact factor: 14.919
  4 in total
  5 in total

Review 1.  Structure, mechanism, and regulation of polycomb-repressive complex 2.

Authors:  Lindsay E Moritz; Raymond C Trievel
Journal:  J Biol Chem       Date:  2017-09-14       Impact factor: 5.157

Review 2.  Structure of the PRC2 complex and application to drug discovery.

Authors:  Yi Shi; Xiao-Xi Wang; You-Wen Zhuang; Yi Jiang; Karsten Melcher; H Eric Xu
Journal:  Acta Pharmacol Sin       Date:  2017-04-17       Impact factor: 6.150

3.  A Polycomb repressive complex is required for RNAi-mediated heterochromatin formation and dynamic distribution of nuclear bodies.

Authors:  Jing Xu; Xiaolu Zhao; Fengbiao Mao; Venkatesha Basrur; Beatrix Ueberheide; Brian T Chait; C David Allis; Sean D Taverna; Shan Gao; Wei Wang; Yifan Liu
Journal:  Nucleic Acids Res       Date:  2021-06-04       Impact factor: 16.971

Review 4.  PRC2 is high maintenance.

Authors:  Jia-Ray Yu; Chul-Hwan Lee; Ozgur Oksuz; James M Stafford; Danny Reinberg
Journal:  Genes Dev       Date:  2019-05-23       Impact factor: 11.361

5.  The EZH2 SANT1 domain is a histone reader providing sensitivity to the modification state of the H4 tail.

Authors:  Tyler M Weaver; Jiachen Liu; Katelyn E Connelly; Chris Coble; Katayoun Varzavand; Emily C Dykhuizen; Catherine A Musselman
Journal:  Sci Rep       Date:  2019-01-30       Impact factor: 4.379
  5 in total

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