Zhengxiang Luo1, Zhongrun Qian1, Kun Yang1, Hongyi Liu2, Wenbin Zhang3, Yanjun Zeng4. 1. Department of Neurosurgery, NanJing Brain Hospital affiliated with NanJing Medical University, NanJing, China. 2. Department of Neurosurgery, NanJing Brain Hospital affiliated with NanJing Medical University, NanJing, China. Electronic address: hyliu18@126.com. 3. Department of Neurosurgery, NanJing Brain Hospital affiliated with NanJing Medical University, NanJing, China. Electronic address: barton-zhang@163.com. 4. Biomechanics and Medical Information Institute, Beijing University of Technology, Beijing, China.
Abstract
BACKGROUND: Primary intracranial germinomas occurring in the cerebral hemisphere are extremely rare, with only a few reported cases in the literature. We describe an unusual case of a primary germinoma that developed in the insular lobe, with little involvement in the basal frontal lobe. CASE DESCRIPTION: A 19-year-old man presented with headache and vomiting. Magnetic resonance imaging showed a solitary, ring-like enhanced lesion in the left hemisphere, and a preliminary diagnosis of glioma was made. Surgery was performed, and the diagnosis of germinoma was made based on the histopathologic results. CONCLUSIONS: The causes of ectopic germinomas of the midline structures of the brain are still unclear, but the theory of misplacement may partially clarify this phenomenon. Reflecting a lack of definitive management guidelines for atypical germinoma, the present patient was treated with focal radiotherapy around the lesion after surgery and achieved remission by 34 months postoperatively.
BACKGROUND:Primary intracranial germinomas occurring in the cerebral hemisphere are extremely rare, with only a few reported cases in the literature. We describe an unusual case of a primary germinoma that developed in the insular lobe, with little involvement in the basal frontal lobe. CASE DESCRIPTION: A 19-year-old man presented with headache and vomiting. Magnetic resonance imaging showed a solitary, ring-like enhanced lesion in the left hemisphere, and a preliminary diagnosis of glioma was made. Surgery was performed, and the diagnosis of germinoma was made based on the histopathologic results. CONCLUSIONS: The causes of ectopic germinomas of the midline structures of the brain are still unclear, but the theory of misplacement may partially clarify this phenomenon. Reflecting a lack of definitive management guidelines for atypical germinoma, the present patient was treated with focal radiotherapy around the lesion after surgery and achieved remission by 34 months postoperatively.
Authors: Jarnail Bal; Michael Bruneau; Moncef Berhouma; Jan F Cornelius; Luigi M Cavallo; Roy T Daniel; Sebastien Froelich; Emmanuel Jouanneau; Torstein R Meling; Mahmoud Messerer; Pierre-Hugues Roche; Henry Schroeder; Marcos Tatagiba; Idoya Zazpe; Dimitrios Paraskevopoulos Journal: Acta Neurochir (Wien) Date: 2021-12-02 Impact factor: 2.216
Authors: Christopher Lauren; Donny Argie; Elric B Malelak; Reza Mawardy; Samuel E Suranta; Vito M Junaidy; Yohanes Firmansyah Journal: J Neurosurg Case Lessons Date: 2021-04-05