Juan E Corral1, Tara Keihanian2, Paul T Kröner3, Ryan Dauer2, Frank J Lukens1, Daniel A Sussman4. 1. a Division of Gastroenterology and Hepatology , Mayo Clinic , Jacksonville , FL , USA. 2. b Department of Medicine , University of Miami Miller School of Medicine - Jackson Memorial Hospital , Miami , FL , USA. 3. c Department of Medicine , Mount Sinai, St. Luke's, and Roosevelt Hospitals, Icahn School of Medicine at Mount Sinai , New York , NY , USA. 4. d Division of Gastroenterology, Department of Medicine , University of Miami Miller School of Medicine , Miami , FL , USA.
Abstract
BACKGROUND/ OBJECTIVE: Hiatal hernia is considered to be a predisposing factor to develop Mallory-Weiss Syndrome (MWS). No large case-control studies verifying this hypothesis have been conducted. METHODS: We reviewed all esophagogastroduodenoscopies with findings of MWS (n = 2342) in a national database and compared with age and gender-matched controls (n = 9368). Demographics, endoscopic characteristics and presence of a hiatal hernia were compared between both groups. Average age was 56.7 ± 18.6 years, and 72.4% were male. RESULTS: Hiatal hernia was more common in controls, and no significant difference was seen in a multivariate analysis. CONCLUSION: Dynamic changes inducing mucosal tension are more relevant determinants to develop MWS than gastro-esophageal junction location alone.
BACKGROUND/ OBJECTIVE:Hiatal hernia is considered to be a predisposing factor to develop Mallory-Weiss Syndrome (MWS). No large case-control studies verifying this hypothesis have been conducted. METHODS: We reviewed all esophagogastroduodenoscopies with findings of MWS (n = 2342) in a national database and compared with age and gender-matched controls (n = 9368). Demographics, endoscopic characteristics and presence of a hiatal hernia were compared between both groups. Average age was 56.7 ± 18.6 years, and 72.4% were male. RESULTS:Hiatal hernia was more common in controls, and no significant difference was seen in a multivariate analysis. CONCLUSION: Dynamic changes inducing mucosal tension are more relevant determinants to develop MWS than gastro-esophageal junction location alone.