Literature DB >> 28005422

Multilevel, Dynamic Chronic Obstructive Pulmonary Disease Heterogeneity. A Challenge for Personalized Medicine.

Rosa Faner1,2, Álvar Agustí1,2,3,4,5.   

Abstract

This article summarizes how the multilevel (clinical, functional, structural, and biological) and dynamic (i.e., subjected to changes with time) heterogeneity of chronic obstructive pulmonary disease challenges a personalized approach for these patients. In particular, the following issues are discussed: (1) the conceptual differences between personalized and precision medicine, (2) how to frame the complexity and heterogeneity of chronic obstructive pulmonary disease by considering the precise meaning of the terms personalized medicine and precision medicine, and (3) how to translate all these novel concepts into clinical practice and move the field forward.

Entities:  

Keywords:  biomarkers; bronchitis; emphysema; lung function; network analysis

Mesh：

Year:  2016        PMID： 28005422     DOI： 10.1513/AnnalsATS.201605-372AW

Source DB:  PubMed          Journal:  Ann Am Thorac Soc        ISSN： 2325-6621


  6 in total

1.  Bronchodilator Response in Patients with COPD, Asthma-COPD-Overlap (ACO) and Asthma, Evaluated by Plethysmographic and Spirometric z-Score Target Parameters.

Authors:  Richard Kraemer; Hans-Jürgen Smith; Fabian Gardin; Jürg Barandun; Stefan Minder; Lukas Kern; Martin H Brutsche
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2021-09-01

Review 2.  The Emerging Role of Extracellular Vesicles Detected in Different Biological Fluids in COPD.

Authors:  Tommaso Neri; Alessandro Celi; Mariaenrica Tinè; Nicol Bernardinello; Manuel G Cosio; Marina Saetta; Dario Nieri; Erica Bazzan
Journal:  Int J Mol Sci       Date:  2022-05-05       Impact factor: 6.208

Review 3.  Precision medicine in COPD: where are we and where do we need to go?

Authors:  Venkataramana K Sidhaye; Kristine Nishida; Fernando J Martinez
Journal:  Eur Respir Rev       Date:  2018-08-01

Review 4.  Individual trajectory-based care for COPD: getting closer, but not there yet.

Authors:  Nicolas Roche; Philippe Devillier; Patrick Berger; Arnaud Bourdin; Daniel Dusser; Jean-François Muir; Yan Martinat; Philippe Terrioux; Bruno Housset
Journal:  ERJ Open Res       Date:  2021-12-13

5.  Chronic Obstructive Pulmonary Disease (COPD) as a disease of early aging: Evidence from the EpiChron Cohort.

Authors:  Miguel J Divo; Bartolome R Celli; Beatriz Poblador-Plou; Amaia Calderón-Larrañaga; Juan Pablo de-Torres; Luis A Gimeno-Feliu; Juan Bertó; Javier J Zulueta; Ciro Casanova; Victor M Pinto-Plata; Carlos Cabrera-Lopez; Francesca Polverino; Jonás Carmona Píréz; Alexandra Prados-Torres; Jose M Marin
Journal:  PLoS One       Date:  2018-02-22       Impact factor: 3.240

6.  Coupled Immunological and Biomechanical Model of Emphysema Progression.

Authors:  Mario Ceresa; Andy L Olivares; Jérôme Noailly; Miguel A González Ballester
Journal:  Front Physiol       Date:  2018-04-19       Impact factor: 4.566
  6 in total

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