Literature DB >> 28004944

Phomopsterones A and B, Two Functionalized Ergostane-Type Steroids from the Endophytic Fungus Phomopsis sp. TJ507A.

Zhengxi Hu, Ye Wu, Shuangshuang Xie, Weiguang Sun, Yi Guo, Xiao-Nian Li1, Junjun Liu, Hua Li, Jianping Wang, Zengwei Luo, Yongbo Xue, Yonghui Zhang.   

Abstract

Two new functionalized ergostane-type steroids, phomopsterones A (1) and B (2), were isolated from the plant-derived Phomopsis sp. TJ507A. Their structures were determined on the basis of spectroscopic data, a modified Mosher's method, X-ray crystallographic analysis, and quantum chemical calculations. Compound 1 is an unprecedented ergosteroid featuring a rearranged bicyclo[3.3.1]nonane motif resulting from B-ring scission and a subsequent 180° rotation of the ring A during biosynthesis. Compound 2 exhibited anti-inflammatory activity.

Entities:  

Year:  2016        PMID： 28004944     DOI： 10.1021/acs.orglett.6b03557

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  8 in total

1.  Anti-inflammatory butenolide derivatives from the coral-derived fungus Aspergillus terreus and structure revisions of aspernolides D and G, butyrolactone VI and 4',8''-diacetoxy butyrolactone VI.

Authors:  Mengting Liu; Qun Zhou; Jianping Wang; Junjun Liu; Changxing Qi; Yongji Lai; Hucheng Zhu; Yongbo Xue; Zhengxi Hu; Yonghui Zhang
Journal:  RSC Adv       Date:  2018-04-09       Impact factor: 4.036

2.  α-Glucosidase Inhibitors From the Coral-Associated Fungus Aspergillus terreus.

Authors:  Mengting Liu; Changxing Qi; Weiguang Sun; Ling Shen; Jianping Wang; Junjun Liu; Yongji Lai; Yongbo Xue; Zhengxi Hu; Yonghui Zhang
Journal:  Front Chem       Date:  2018-09-13       Impact factor: 5.221

3.  Mycophenolic Acid Derivatives with Immunosuppressive Activity from the Coral-Derived Fungus Penicillium bialowiezense.

Authors:  Qing Zhang; Beiye Yang; Fengli Li; Mengting Liu; Shuang Lin; Jianping Wang; Yongbo Xue; Hucheng Zhu; Weiguang Sun; Zhengxi Hu; Yonghui Zhang
Journal:  Mar Drugs       Date:  2018-07-07       Impact factor: 5.118

Review 4.  Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review.

Authors:  Rufin Marie Kouipou Toghueo
Journal:  Nat Prod Bioprospect       Date:  2019-09-28

5.  Bioactive α-Pyrone Derivatives from the Endophytic Fungus Diaporthe sp. CB10100 as Inducible Nitric Oxide Synthase Inhibitors.

Authors:  Hong Pu; Jianxin Liu; Yeji Wang; Yuhui Peng; Wanying Zheng; Yang Tang; Boping Hui; Chunmei Nie; Xueshuang Huang; Yanwen Duan; Yong Huang
Journal:  Front Chem       Date:  2021-05-18       Impact factor: 5.221

Review 6.  Structure and Biological Activity of Ergostane-Type Steroids from Fungi.

Authors:  Vladimir N Zhabinskii; Pavel Drasar; Vladimir A Khripach
Journal:  Molecules       Date:  2022-03-24       Impact factor: 4.411

7.  Aspermerodione, a novel fungal metabolite with an unusual 2,6-dioxabicyclo[2.2.1]heptane skeleton, as an inhibitor of penicillin-binding protein 2a.

Authors:  Yuben Qiao; Xiaotian Zhang; Yan He; Weiguang Sun; Wenya Feng; Junjun Liu; Zhengxi Hu; Qianqian Xu; Hucheng Zhu; Jinwen Zhang; Zengwei Luo; Jianping Wang; Yongbo Xue; Yonghui Zhang
Journal:  Sci Rep       Date:  2018-04-03       Impact factor: 4.379

8.  Highly Substituted Benzophenone Aldehydes and Eremophilane Derivatives from the Deep-Sea Derived Fungus Phomopsis lithocarpus FS508.

Authors:  Jian-Lin Xu; Hong-Xin Liu; Yu-Chan Chen; Hai-Bo Tan; Heng Guo; Li-Qiong Xu; Sai-Ni Li; Zi-Lei Huang; Hao-Hua Li; Xiao-Xia Gao; Wei-Min Zhang
Journal:  Mar Drugs       Date:  2018-09-11       Impact factor: 5.118
  8 in total

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