| Literature DB >> 28004875 |
Huseyin Erguven1, David C Leitch1, Evan N Keyzer1, Bruce A Arndtsen1.
Abstract
We describe here the development and structural characterization of a new type of mesoionic 1,3-dipole, which can be generated in the one-step reaction of imines with pyridine- or quinoline-based acid chlorides. Coupling the formation of these dipoles with alkyne cycloaddition can open a general and modular route to synthesize indolizines from combinations of available and diversifiable building blocks.Entities:
Keywords: 1,3 dipolar cycloaddition; heterocycles; indolizines; mesoionic dipoles; multicomponent reactions
Year: 2016 PMID： 28004875 DOI： 10.1002/anie.201609726
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336