Vijay Chidambaram1, James D Brierley2, Bernard Cummings2, Rajesh Bhayana3, Ravi J Menezes4, Erin D Kennedy5, Richard Kirsch6, Kartik S Jhaveri7,8. 1. Royal Liverpool and Broadgreen University Hospitals, NHS Trust, Prescot Street, Liverpool, L7 8XP, UK. 2. Department of Radiation Oncology, Princess Margaret Cancer Centre, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, ON, M5G 2M9, Canada. 3. Department of Medical Imaging, JDMI Research, University of Toronto, 2nd Floor, North Side, 700 University Avenue, Toronto, ON, M5G 1X6, Canada. 4. Joint Department of Medical Imaging, JDMI Research, University Health Network, 2nd Floor, North Side, 700 University Avenue, Toronto, ON, M5G 1X6, Canada. 5. Division of General Surgery, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, ON, M5G 1X5, Canada. 6. Pathology & Lab Medicine Department, Mount Sinai Hospital, University of Toronto, 600 University Ave. Rm 6-500-10, Toronto, ON, M5G 1X5, Canada. 7. Joint Department of Medical Imaging, University Health Network, Mount Sinai Hospital and Women's College Hospital, University of Toronto, 610 University Ave, 3-957, Toronto, ON, M5G 2M9, Canada. Kartik.jhaveri@uhn.ca. 8. Department of Radiology, Princess Margaret Hospital, University of Toronto, 610 University Ave, 3-957, Toronto, ON, M5G 2M9, Canada. Kartik.jhaveri@uhn.ca.
Abstract
PURPOSE: To investigate the relationship of pre-treatment volumetric apparent diffusion coefficient (ADC) histogram parameters with post-operative histopathologic treatment response and clinical outcomes following pre-operative chemoradiation treatment (CRT) in rectal cancer. MATERIALS AND METHODS: In a Health Insurance Portability and Accountability Act compliant retrospective study, 78 rectal cancer patients treated with pre-operative CRT and rectal MRI were included. MR imaging analysis was performed using OncoTREAT (software tool). Multiple volumetric ADC histogram parameters (voxel distribution across ADC ranges, kurtosis, and skewness) were assessed. Correlation was made to post-operative pathological complete response, clinical, or radiological evidence of disease progression using the Mann-Whitney test. RESULTS: Post CRT, 8 patients showed pathologic complete response and 13 patients showed distant disease progression. Pre-treatment mean ADC was 1.2 × 10-3 mm2/s (range 0.3-1.99 × 10-3 mm2/s). Mean kurtosis measured was 0.56 (range -1 to 6; SD 1.36). Mean skewness was 0.3 (range -1 to 2; SD 0.69). Skewness had significant correlation (p value = 0.006) with disease progression. The mean rectal tumor volume was 24cc (range 1cc-134cc). Pre-treatment MRI tumor volume showed significant correlation (p value = 0.013) with pathologic complete response. Mean ADC and percentage voxels distribution against ADC ranges had no significant correlation with treatment response or disease outcomes. CONCLUSION: Volumetric ADC histogram analysis of pre-CRT rectal cancer MRI appears promising for prediction of post-CRT complete response and disease progression.
PURPOSE: To investigate the relationship of pre-treatment volumetric apparent diffusion coefficient (ADC) histogram parameters with post-operative histopathologic treatment response and clinical outcomes following pre-operative chemoradiation treatment (CRT) in rectal cancer. MATERIALS AND METHODS: In a Health Insurance Portability and Accountability Act compliant retrospective study, 78 rectal cancerpatients treated with pre-operative CRT and rectal MRI were included. MR imaging analysis was performed using OncoTREAT (software tool). Multiple volumetric ADC histogram parameters (voxel distribution across ADC ranges, kurtosis, and skewness) were assessed. Correlation was made to post-operative pathological complete response, clinical, or radiological evidence of disease progression using the Mann-Whitney test. RESULTS: Post CRT, 8 patients showed pathologic complete response and 13 patients showed distant disease progression. Pre-treatment mean ADC was 1.2 × 10-3 mm2/s (range 0.3-1.99 × 10-3 mm2/s). Mean kurtosis measured was 0.56 (range -1 to 6; SD 1.36). Mean skewness was 0.3 (range -1 to 2; SD 0.69). Skewness had significant correlation (p value = 0.006) with disease progression. The mean rectal tumor volume was 24cc (range 1cc-134cc). Pre-treatment MRI tumor volume showed significant correlation (p value = 0.013) with pathologic complete response. Mean ADC and percentage voxels distribution against ADC ranges had no significant correlation with treatment response or disease outcomes. CONCLUSION: Volumetric ADC histogram analysis of pre-CRT rectal cancer MRI appears promising for prediction of post-CRT complete response and disease progression.
Authors: Iram Shahzadi; Alex Zwanenburg; Annika Lattermann; Annett Linge; Christian Baldus; Jan C Peeken; Stephanie E Combs; Markus Diefenhardt; Claus Rödel; Simon Kirste; Anca-Ligia Grosu; Michael Baumann; Mechthild Krause; Esther G C Troost; Steffen Löck Journal: Sci Rep Date: 2022-06-17 Impact factor: 4.996
Authors: Qiaoyu Xu; Yanyan Xu; Hongliang Sun; Tao Jiang; Sheng Xie; Bee Yen Ooi; Yi Ding Journal: Cancer Manag Res Date: 2021-06-01 Impact factor: 3.989