| Literature DB >> 28004020 |
Pankaj Sharma1, Veena Mittal1, Mala Chhabra1, Roop Kumari2, Priyanka Singh3, Srinivas Venkatesh4.
Abstract
Dengue virus type 2 (DENV-2) has been associated with severe dengue outbreaks in many countries including India. Its predominance was recorded nearly after a decade in the capital city, Delhi in 2013. The present study characterizes DENV-2 circulated during 2013-2014. Analysis based on envelope (E) gene showed the presence of two clades (I and II) of DENV-2, within the Cosmopolitan genotype. Analysis of time of most recent common ancestor revealed the existence of clade I for more than a decade (95 % HPD 13-16 years) however, clade II showed comparatively recent emergence (95 % HPD 5-13 years). Presence of different clades is of high significance as this may result in increased virus transmission and major outbreaks. Further, the presence of a unique amino acid substitution, Q325H was also observed in an isolate; 14/D2/Del/2013 (KT717981). This substitution falls in immune epitope (epitope id: 150268) and may have important role in host immune response.Entities:
Keywords: Dengue; Envelope; Evolutionary analysis; Molecular epidemiology
Year: 2016 PMID： 28004020 PMCID： PMC5142591 DOI： 10.1007/s13337-016-0346-4
Source DB: PubMed Journal: Virusdisease ISSN： 2347-3584