Franziska Scheibe1, Harald Prüss2, Annerose M Mengel2, Siegfried Kohler2, Astrid Nümann2, Martin Köhnlein2, Klemens Ruprecht2, Tobias Alexander2, Falk Hiepe2, Andreas Meisel2. 1. From the Department of Neurology (F.S., H.P., A.M.M., S.K., A.N., M.K., K.R., A.M.), German Center for Neurodegenerative Diseases (H.P.), NeuroCure Clinical Research Center (S.K., A.M.), Department of Rheumatology and Clinical Immunology (T.A., F.H.), and Center for Stroke Research Berlin (A.M.), Charité-Universitätsmedizin Berlin, Germany. franziska.scheibe@charite.de. 2. From the Department of Neurology (F.S., H.P., A.M.M., S.K., A.N., M.K., K.R., A.M.), German Center for Neurodegenerative Diseases (H.P.), NeuroCure Clinical Research Center (S.K., A.M.), Department of Rheumatology and Clinical Immunology (T.A., F.H.), and Center for Stroke Research Berlin (A.M.), Charité-Universitätsmedizin Berlin, Germany.
Abstract
OBJECTIVE: We assessed the therapeutic potential of the plasma-cell-depleting proteasome inhibitor bortezomib in severe and therapy-refractory cases of anti-NMDA receptor (anti-NMDAR) encephalitis. METHODS: Five severely affected patients with anti-NMDAR encephalitis with delayed treatment response or resistance to standard immunosuppressive and B-cell-depleting drugs (corticosteroids, IV immunoglobulins, plasma exchange, immunoadsorption, rituximab, cyclophosphamide) who required medical treatment and artificial ventilation on intensive care units were treated with 1-6 cycles of 1.3 mg/m2 bortezomib. Occurrence of adverse events was closely monitored. RESULTS: Bortezomib treatment showed clinical improvement or disease remission, which was accompanied by a partial NMDAR antibody titer decline in 4 of 5 patients. With respect to disease severity, addition of bortezomib to the multimodal immunosuppressive treatment regimen was associated with an acceptable safety profile. CONCLUSIONS: Our study identifies bortezomib as a promising escalation therapy for severe and therapy-refractory anti-NMDAR encephalitis. CLASSIFICATION OF EVIDENCE: This retrospective case series provides Class IV evidence that bortezomib reduces antibody titers and improves the clinical course of patients with severe anti-NMDAR encephalitis.
OBJECTIVE: We assessed the therapeutic potential of the plasma-cell-depleting proteasome inhibitor bortezomib in severe and therapy-refractory cases of anti-NMDA receptor (anti-NMDAR) encephalitis. METHODS: Five severely affected patients with anti-NMDAR encephalitis with delayed treatment response or resistance to standard immunosuppressive and B-cell-depleting drugs (corticosteroids, IV immunoglobulins, plasma exchange, immunoadsorption, rituximab, cyclophosphamide) who required medical treatment and artificial ventilation on intensive care units were treated with 1-6 cycles of 1.3 mg/m2 bortezomib. Occurrence of adverse events was closely monitored. RESULTS:Bortezomib treatment showed clinical improvement or disease remission, which was accompanied by a partial NMDAR antibody titer decline in 4 of 5 patients. With respect to disease severity, addition of bortezomib to the multimodal immunosuppressive treatment regimen was associated with an acceptable safety profile. CONCLUSIONS: Our study identifies bortezomib as a promising escalation therapy for severe and therapy-refractory anti-NMDAR encephalitis. CLASSIFICATION OF EVIDENCE: This retrospective case series provides Class IV evidence that bortezomib reduces antibody titers and improves the clinical course of patients with severe anti-NMDAR encephalitis.